Glioma Cell Biology

  • Aleksi Sedo
  • Rolf Mentlein

Table of contents

  1. Front Matter
    Pages i-x
  2. The Inner Space: Molecular Mechanisms Driving the Malignant Phenotype of Glioma Cells

    1. Front Matter
      Pages 1-1
    2. Petra Hamerlik
      Pages 3-22
    3. Vinay K. Puduvalli
      Pages 23-45
    4. Mitsutoshi Nakada, Daisuke Kita, Takuya Furuta, Takuya Watanabe, Yutaka Hayashi, Jun-Ichiro Hamada
      Pages 47-75
    5. Jiri Sana, Andrej Besse, Ondrej Slaby
      Pages 77-116
    6. Iwona Anna Ciechomska, Aleksandra Ellert-Miklaszewska, Bozena Kaminska
      Pages 117-149
  3. Partnership: Glioma Cell Partners and the Tumor Microenvironment

    1. Front Matter
      Pages 151-151
    2. Kirsten Hattermann, Rolf Mentlein
      Pages 153-185
    3. Mujeeburahim Cheerathodi, Joseph H. McCarty
      Pages 187-219
    4. Selby Chen, Ian F. Parney
      Pages 221-239
    5. Bozena Kaminska
      Pages 241-270
    6. Christian Mawrin, Constanze Seidenbecher
      Pages 271-292
    7. Vivaldo Moura-Neto, Loraine Campanati, Diana Matias, Claudia Maria Pereira, Catarina Freitas, Juliana M. Coelho-Aguiar et al.
      Pages 293-315
    8. Petr Busek, Martin Prevorovsky, Evzen Krepela, Aleksi Sedo
      Pages 317-395
  4. Interactions: Concepts and Tools in Glioma Research

    1. Front Matter
      Pages 397-397
    2. Paolo Malatesta, Filippo Calzolari, Irene Appolloni
      Pages 399-431
    3. Imad Saeed Khan, Moneeb Ehtesham
      Pages 433-453
  5. Back Matter
    Pages 455-468

About this book


Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions),  tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology


Brain Glioblastoma Glioma Tumor Tumor Angiogenesis Tumorigenesis

Editors and affiliations

  • Aleksi Sedo
    • 1
  • Rolf Mentlein
    • 2
  1. 1.Biochemistry and Experimental OncologyCharles University Prague 1st Faculty of MedicinePragueCzech Republic
  2. 2.Anatomisches InstitutChristian-Albrechts-Universität zu KielKielGermany

Bibliographic information