Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

  • Hartmut Geiger
  • Heinrich Jasper
  • Maria Carolina Florian

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Heinrich Jasper
      Pages 3-15
  3. Mechanisms of Stem Cell Aging: Lessons from Model Organisms

    1. Front Matter
      Pages 17-17
    2. Chong He, Brian K. Kennedy
      Pages 19-49
    3. Chih-chun Janet Lin, Meng Carla Wang
      Pages 51-70
    4. Hila Toledano, D. Leanne Jones
      Pages 71-84
  4. Mechanisms of Stem Cell Aging in Mammalian Tissues

    1. Front Matter
      Pages 105-105
    2. Edyta Wόjtowicz, Evgenia Verovskaya, Gerald de Haan
      Pages 107-125
    3. David Garrick, Dounia Djeghloul, Klaudia Kuranda, Michele Goodhardt
      Pages 127-147
    4. Sabrina Gundermann, Hans-Jürgen Stark, Petra Boukamp
      Pages 149-174
    5. Tobias Sperka, Lenhard Rudolph
      Pages 175-194
    6. Bryon R. McKay, Gianni Parise
      Pages 195-226
    7. Günter Lepperdinger, Stephan Reitinger
      Pages 227-244
    8. Jose A. Cancelas, Kyung-Hee Chang
      Pages 245-256
  5. Stem Cells, Diseases of Aging and Rejuvenation

    1. Front Matter
      Pages 257-257
    2. Curtis J. Henry, Andrii I. Rozhok, James DeGregori
      Pages 259-286
    3. Dongsheng Jiang, Karin Scharffetter-Kochanek
      Pages 287-318
    4. Mark Gutierrez, Deepak A. Lamba
      Pages 319-341
    5. Maria Carolina Florian, Hartmut Geiger
      Pages 343-354

About this book


Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems, and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.


Aging Cell biology Myeloproliferative Diseases Rejuvenation Stem cells

Editors and affiliations

  • Hartmut Geiger
    • 1
  • Heinrich Jasper
    • 2
  • Maria Carolina Florian
    • 3
  1. 1.Dermatology and Allergic DiseasesUlm UniversityUlmGermany
  2. 2.Department of BiologyUniversity of RochesterRochesterUSA
  3. 3.Dermatology and Allergic DiseasesUlm UniversityUlmGermany

Bibliographic information