Drug Resistance in Leishmania Parasites

Consequences, Molecular Mechanisms and Possible Treatments

  • Alicia Ponte-Sucre
  • Emilia Diaz
  • Maritza Padrón-Nieves

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Determinant Features in Leishmaniasis

    1. Front Matter
      Pages 13-13
    2. Gabriele Schönian, Elisa Cupolillo, Isabel Mauricio
      Pages 15-44
    3. Lenea Campino, Carla Maia
      Pages 45-64
    4. Jean-Claude Dujardin, Saskia Decuypere
      Pages 65-83
  3. Leishmania and the Immune System

    1. Front Matter
      Pages 85-85
    2. Lukasz Kedzierski, Krystal J. Evans
      Pages 87-112
    3. Katrin Färber, Heidrun Moll
      Pages 113-141
    4. Bhavana Sethu Lakshmi, Rentala Madhubala
      Pages 143-163
  4. Challenges in the Diagnosis, Treatment and Control of Leishmaniasis in Times of Drug Resistance

    1. Front Matter
      Pages 165-165
    2. Margriet den Boer, Luis Rivas, Jorge Alvar
      Pages 167-181
    3. Shyam Sundar, Jaya Chakravarty
      Pages 183-198
    4. Olga Zerpa, Alicia Ponte-Sucre
      Pages 199-211
  5. Molecular Features of Drug-Resistant Leishmania

    1. Front Matter
      Pages 213-213
    2. Patricia Cuervo, Jose Batista de Jesus
      Pages 215-236
    3. Adriano C. Coelho, Paulo C. Cotrim
      Pages 237-258
    4. Mitali Chatterjee
      Pages 285-297
  6. Pharmacology and Chemotherapy of Leishmaniasis

    1. Front Matter
      Pages 299-299
    2. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley
      Pages 301-319
    3. Philippe M. Loiseau, Gillian Barratt
      Pages 321-350
    4. Francisco Gamarro, María P. Sánchez-Cañete, Santiago Castanys
      Pages 351-379
  7. Strategies to Circumvent Drug Resistance in Leishmania

    1. Front Matter
      Pages 405-405
    2. Louis Maes, Paul Cos, Simon L. Croft
      Pages 407-429
    3. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves
      Pages 431-449
  8. Back Matter
    Pages 451-459

About this book


One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.


ABC Transporters Drug Resistance Infectious Disease Leishmaniasis Parasite Vaccine Development

Editors and affiliations

  • Alicia Ponte-Sucre
    • 1
  • Emilia Diaz
    • 2
  • Maritza Padrón-Nieves
    • 3
  1. 1.Fac. Medicina, Instituto de Medicina ExperimentalUniversidad Central de VenezuelaCaracasVenezuela
  2. 2.Universidad Central de VenezuelaCaracasVenezuela
  3. 3.Universidad Central de VenezuelaCaracasVenezuela

Bibliographic information