Proteases: Structure and Function

  • Klaudia Brix
  • Walter Stöcker

Table of contents

  1. Front Matter
    Pages i-xii
  2. Antonio Baici, Marko Novinec, Brigita Lenarčič
    Pages 37-84
  3. Klaudia Brix, Christopher J. Scott, Margarete M. S. Heck
    Pages 85-125
  4. Ann H. Erickson, Ciro Isidoro, Lukas Mach, John S. Mort
    Pages 127-173
  5. Stefan Tholen, Maria Magdalena Koczorowska, Zon Weng Lai, Joern Dengjel, Oliver Schilling
    Pages 175-216
  6. Martina Gansz, Ursula Kern, Christoph Peters, Thomas Reinheckel
    Pages 217-233
  7. Walter Stöcker, F. Xavier Gomis-Rüth
    Pages 235-263
  8. Andreas Flütsch, Markus G. Grütter
    Pages 265-302
  9. Holger Cynis, Stefan F. Lichtenthaler, Leona Wagner, Hans-Ulrich Demuth
    Pages 319-371
  10. S. Gaylen Bradley, Toni M. Antalis, Judith S. Bond
    Pages 373-393
  11. John Anagli, Kevin K. W. Wang, Yasuko Ono, Hiroyuki Sorimachi
    Pages 395-431
  12. Agnès Noel, Nor Eddine Sounni
    Pages 471-489
  13. Bonnie F. Sloane, Karin List, Barbara Fingleton, Lynn Matrisian
    Pages 491-550
  14. Back Matter
    Pages 551-564

About this book


Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.


enzyme proteinase proteinase function proteinase structure

Editors and affiliations

  • Klaudia Brix
    • 1
  • Walter Stöcker
    • 2
  2. 2.Institute of ZoologyJohannes Gutenberg University MainzMainzGermany

Bibliographic information