Gene Vaccines

  • Josef Thalhamer
  • Richard Weiss
  • Sandra Scheiblhofer

Table of contents

  1. Front Matter
    Pages i-xi
  2. Richard Weiss, Viggo Van Tendeloo, Sandra Scheiblhofer, Josef Thalhamer
    Pages 1-35
  3. Bin Wang, Youmin Kang, Richard Ascione
    Pages 89-107
  4. Glen Perera, Andreas Bernkop-Schnürch
    Pages 109-125
  5. Eszter Nátz, Julianna Lisziewicz
    Pages 127-143
  6. Arielle A. Ginsberg, Xuefei Shen, Natalie A. Hutnick, David B. Weiner
    Pages 145-162
  7. Thomas M. Kündig, Adrian Bot, Gabriela Senti
    Pages 205-221
  8. Jochen Probst, Mariola Fotin-Mleczek, Thomas Schlake, Andreas Thess, Thomas Kramps, Karl-Josef Kallen
    Pages 223-245
  9. Richard Weiss, Sandra Scheiblhofer, Elisabeth Rösler, Josef Thalhamer
    Pages 247-263
  10. Bettina Klug, Jens Reinhardt, James Robertson
    Pages 285-295
  11. Peter Mayrhofer, Michaela Iro
    Pages 297-310
  12. Jochen Urthaler, Hermann Schuchnigg, Patrick Garidel, Hans Huber
    Pages 311-330

About this book

Introduction

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

Keywords

RNA and DNA vaccines antigen-specific gene vaccines immune response vaccination

Editors and affiliations

  • Josef Thalhamer
    • 1
  • Richard Weiss
    • 2
  • Sandra Scheiblhofer
    • 3
  1. 1., Department of Molecular BiologyUniversity of SalzburgSalzburgAustria
  2. 2., Department of Molecular BiologyUniversity of SalzburgSalzburgAustria
  3. 3., Department of Molecular BiologyUniversity of SalzburgSalzburgAustria

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-0439-2
  • Copyright Information Springer-Verlag/Wien 2012
  • Publisher Name Springer, Vienna
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-7091-0438-5
  • Online ISBN 978-3-7091-0439-2
  • About this book