Biosimulation in Biomedical Research, Health Care and Drug Development

  • Erik Mosekilde
  • Olga Sosnovtseva
  • Amin Rostami-Hodjegan

Table of contents

  1. Front Matter
    Pages i-xv
  2. Steen G. Dawids, Jakob L. Laugesen, Erik Mosekilde
    Pages 1-18
  3. Ole Lund, Jakob L. Laugesen, Erik Mosekilde
    Pages 19-41
  4. Jakob L. Laugesen, Erik Mosekilde
    Pages 43-68
  5. Jakob L. Laugesen, Erik Mosekilde
    Pages 69-95
  6. Svetlana Postnova, Christian Finke, Martin T. Huber, Karl Voigt, Hans A. Braun
    Pages 97-132
  7. D. E. Postnov, N. A. Brazhe, O. V. Sosnovtseva
    Pages 133-151
  8. Alexey R. Brazhe, Georgy V. Maksimov
    Pages 153-177
  9. Anne Beuter, Julien Modolo
    Pages 179-199
  10. Jens Christian Brasen, Jens C. B. Jacobsen, Niels-Henrik Holstein-Rathlou
    Pages 201-218
  11. Jens C. B. Jacobsen, Bjørn O. Hald, Jens C. Brasen, Niels-Henrik Holstein-Rathlou
    Pages 219-236
  12. Jens C. B. Jacobsen, Niels E. Olesen, Niels-Henrik Holstein-Rathlou
    Pages 237-252
  13. Olga V. Sosnovtseva, Dmitry E. Postnov, Natalia B. Janson, Alexander G. Balanov
    Pages 285-310
  14. Elin Nyman, Peter Strålfors, Gunnar Cedersund
    Pages 311-328
  15. Christian Hove Rasmussen, Tue Søeborg, Erik Mosekilde, Morten Colding-Jørgensen
    Pages 329-359
  16. Masoud Jamei, Karen R. Yeo, Trevor N. Johnson, Cyrus Ghobadi, Manoranjenni Chetty, Khaled Abduljalil et al.
    Pages 361-386
  17. Back Matter
    Pages 387-396

About this book


Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment.

The book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various cellular and physiological processes, emphasizing particularly the role of self-sustained biological activity. The way how the use of computer models allows optimization of the treatment of various diseases for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides a discussion of the use of models in the pharmaceutical industry, and presents the view of the regulatory agencies on the topic.


Complex biological processes Mechanism based modeling Model-based drug development Model-based healtcare Systems biology

Editors and affiliations

  • Erik Mosekilde
    • 1
  • Olga Sosnovtseva
    • 2
  • Amin Rostami-Hodjegan
    • 3
  1. 1., Department of PhysicsTechnical University of DenmarkKongens LyngbyDenmark
  2. 2., Department of Biomedical SciencesCopenhagen UniversityCopenhagen NDenmark
  3. 3., School of Pharmacy and Pharmaceutical ScUniversity of ManchesterManchesterUnited Kingdom

Bibliographic information