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  • Book
  • © 2011

Ribosomes Structure, Function, and Dynamics

Editors:

  1. Marina V. Rodnina

    1. Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Wolfgang Wintermeyer

    1. Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Rachel Green

    1. Howard Hughes Medical Institute Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First ribosome book since 2001
  • Nobel Prize Chemistry 2009 - The Ribosome
  • Includes chapters of all three Nobel Prize winners
  • Comprehensive in scope
  • Includes supplementary material: sn.pub/extras

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Table of contents (33 chapters)

  1. Decoding, fidelity, and peptidyl transfer

    1. Sense and nonsense recognition by the ribosome

      • Rodrigo F. Ortiz-Meoz, Shan L. He, Hani S. Zaher, Rachel Green
      Pages 213-223

    2. Rate and accuracy of messenger RNA translation on the ribosome

      • Magnus Johansson, Ka Weng Ieong, Johan Åqvist, Michael Y. Pavlov, Måns Ehrenberg
      Pages 225-235

    3. Mutations in 16S rRNA that decrease the fidelity of translation

      • Sean P. McClory, Aishwarya Devaraj, Daoming Qin, Joshua M. Leisring, Kurt Fredrick
      Pages 237-247

    4. Decoding and deafness: Two sides of a coin

      • Rashid Akbergenov, Dmitry Shcherbakov, Tanja Matt, Stefan Duscha, Martin Meyer, Déborah Perez Fernandez et al.
      Pages 249-261

    5. Ribosomal protein S5, ribosome biogenesis and translational fidelity

      • Biswajoy Roy-Chaudhuri, Narayanaswamy Kirthi, Teresa Kelley, Gloria M. Culver
      Pages 263-270

  2. Elongation and ribosome dynamics

    1. Front Matter

      Pages 271-271
      PDF

    3. Real-time monitoring of single-molecule translation

      • Sotaro Uemura, Joseph D. Puglisi
      Pages 295-302

    4. Dynamic views of ribosome function: Energy landscapes and ensembles

      • P. C. Whitford, R. B. Altman, P. Geggier, D. S. Terry, J. B. Munro, J. N. Onuchic et al.
      Pages 303-319

    6. Functions of elongation factor G in translocation and ribosome recycling

      • Wolfgang Wintermeyer, Andreas Savelsbergh, Andrey L. Konevega, Frank Peske, Vladimir I. Katunin, Yuri P. Semenkov et al.
      Pages 329-338

    7. Mechanism and dynamics of the elongation cycle

      • Barry S. Cooperman, Yale E. Goldman, Chunlai Chen, Ian Farrell, Jaskarin Kaur, Hanqing Liu et al.
      Pages 339-348

    8. Studies on the mechanisms of translocation and termination

      • Harry F. Noller, Dmitri N. Ermolenko, Andrei Korostelev, Martin Laurberg, Jianyu Zhu, Haruichi Asahara et al.
      Pages 349-360

    9. The mechanism by which tmRNA rescues stalled ribosomes

      • David Healey, Mickey Miller, Christopher Woolstenhulme, Allen Buskirk
      Pages 361-373

  3. Nascent peptide and tunnel interactions

    1. Front Matter

      Pages 375-375
      PDF

    2. Nascent peptide-mediated ribosome stalling promoted by antibiotics

      • Nora Vázquez-Laslop, Haripriya Ramu, Alexander Mankin
      Pages 377-392

    3. Nascent polypeptide chains within the ribosomal tunnel analyzed by cryo-EM

      • Daniel N. Wilson, Shashi Bhushan, Thomas Becker, Roland Beckmann
      Pages 393-404

  4. Evolution

    1. Front Matter

      Pages 419-419
      PDF

    2. Molecular palaeontology as a new tool to study the evolution of ribosomal RNA

      • Sergey V. Steinberg, Konstantin Bokov
      Pages 421-429
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About this book

The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
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Keywords

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Editors and Affiliations

  • Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

    Marina V. Rodnina, Wolfgang Wintermeyer

  • Howard Hughes Medical Institute Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, USA

    Rachel Green

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About the editors

Dr. Marina V. Rodnina

Prof. Dr. Wolfgang Wintermeyer

MPI for Biophysical Chemistry, Dept. of Physical Biochemistry,  Goettingen, Germany

Dr. Rachel Green

Dept. of Molecular Biology and Genetics, Investigator, Howard Hughes Medical Institute,

Johns Hopkins University School of Medicine, Baltimore, MD, USA

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Bibliographic Information

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Buy it now

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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