Structure, Function, and Dynamics

  • Marina V. Rodnina
  • Wolfgang Wintermeyer
  • Rachel Green

Table of contents

  1. Front Matter
    Pages I-IX
  2. Ribosome structure

    1. Front Matter
      Pages 1-1
    2. C. Axel Innis, Gregor Blaha, David Bulkley, Thomas A. Steitz
      Pages 31-43
    3. Lasse B. Jenner, Natalia Demeshkina, Gulnara Yusupova, Marat Yusupov
      Pages 45-55
    4. Steven T. Gregory, Hasan Demirci, Jennifer F. Carr, Riccardo Belardinelli, Jill R. Thompson, Dale Cameron et al.
      Pages 57-64
    5. Jack A. Dunkle, Jamie H. D. Cate
      Pages 65-73
    6. Adam Ben-Shem, Lasse B. Jenner, Gulnara Yusupova, Marat Yusupov
      Pages 75-81
    7. Rajendra K. Agrawal, Manjuli R. Sharma, Aymen Yassin, Indrajit Lahiri, inda L. Spremulli
      Pages 83-96
    8. Petr V. Sergiev, Anna Y. Golovina, Irina V. Prokhorova, Olga V. Sergeeva, Ilya A. Osterman, Mikhail V. Nesterchuk et al.
      Pages 97-110
  3. Recruiting the ribosome for translation

    1. Front Matter
      Pages 111-111
    2. Angelita Simonetti, Stefano Marzi, Alexander G. Myasnikov, Jean-François Ménétret, Bruno P. Klaholz
      Pages 113-128
    3. Michael Y. Pavlov, Suparna Sanyal, Måns Ehrenberg
      Pages 129-141
    4. Claudio O. Gualerzi, Anna Maria Giuliodori, Anna Brandi, Fabio Di Pietro, Lolita Piersimoni, Attilio Fabbretti et al.
      Pages 143-154
    5. Sarah F. Mitchell, Sarah E. Walker, Vaishnavi Rajagopal, Colin Echeverría Aitken, Jon R. Lorsch
      Pages 155-169
    6. Andrey V. Pisarev, Maxim A. Skabkin, Vera P. Pisareva, Olga V. Skabkina, Christopher U. T. Hellen, Tatyana V. Pestova
      Pages 171-185
  4. Decoding, fidelity, and peptidyl transfer

    1. Front Matter
      Pages 187-187
    2. Jared M. Schrader, Margaret E. Saks, Olke C. Uhlenbeck
      Pages 189-198
    3. Marina V. Rodnina
      Pages 199-212
    4. Rodrigo F. Ortiz-Meoz, Shan L. He, Hani S. Zaher, Rachel Green
      Pages 213-223
    5. Magnus Johansson, Ka Weng Ieong, Johan Åqvist, Michael Y. Pavlov, Måns Ehrenberg
      Pages 225-235
    6. Sean P. McClory, Aishwarya Devaraj, Daoming Qin, Joshua M. Leisring, Kurt Fredrick
      Pages 237-247
    7. Rashid Akbergenov, Dmitry Shcherbakov, Tanja Matt, Stefan Duscha, Martin Meyer, Déborah Perez Fernandez et al.
      Pages 249-261
    8. Biswajoy Roy-Chaudhuri, Narayanaswamy Kirthi, Teresa Kelley, Gloria M. Culver
      Pages 263-270
  5. Elongation and ribosome dynamics

    1. Front Matter
      Pages 271-271
    2. Sotaro Uemura, Joseph D. Puglisi
      Pages 295-302
    3. P. C. Whitford, R. B. Altman, P. Geggier, D. S. Terry, J. B. Munro, J. N. Onuchic et al.
      Pages 303-319
    4. Wolfgang Wintermeyer, Andreas Savelsbergh, Andrey L. Konevega, Frank Peske, Vladimir I. Katunin, Yuri P. Semenkov et al.
      Pages 329-338
    5. Barry S. Cooperman, Yale E. Goldman, Chunlai Chen, Ian Farrell, Jaskarin Kaur, Hanqing Liu et al.
      Pages 339-348
    6. Harry F. Noller, Dmitri N. Ermolenko, Andrei Korostelev, Martin Laurberg, Jianyu Zhu, Haruichi Asahara et al.
      Pages 349-360
    7. David Healey, Mickey Miller, Christopher Woolstenhulme, Allen Buskirk
      Pages 361-373
  6. Nascent peptide and tunnel interactions

    1. Front Matter
      Pages 375-375
    2. Nora Vázquez-Laslop, Haripriya Ramu, Alexander Mankin
      Pages 377-392
    3. Daniel N. Wilson, Shashi Bhushan, Thomas Becker, Roland Beckmann
      Pages 393-404
  7. Evolution

    1. Front Matter
      Pages 419-419
    2. Sergey V. Steinberg, Konstantin Bokov
      Pages 421-429
  8. Back Matter
    Pages 431-442

About this book


The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Editors and affiliations

  • Marina V. Rodnina
    • 1
  • Wolfgang Wintermeyer
    • 1
  • Rachel Green
    • 2
  1. 1.Department of Physical BiochemistryMax Planck Institute for Biophysical ChemistryGöttingenGermany
  2. 2.Howard Hughes Medical Institute Department of Molecular Biology and GeneticsJohns Hopkins University School of MedicineBaltimoreUSA

Bibliographic information