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Theoretical Molecular Biophysics

  • Philipp O.J. Scherer
  • Sighart F. Fischer

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Statistical Mechanics of Biopolymers

    1. Front Matter
      Pages 1-1
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 3-20
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 21-38
  3. Protein Electrostatics and Solvation

    1. Front Matter
      Pages 39-39
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 41-51
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 53-69
    4. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 71-82
  4. Reaction Kinetics

    1. Front Matter
      Pages 83-83
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 85-96
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 97-112
    4. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 113-118
    5. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 119-136
  5. Transport Processes

    1. Front Matter
      Pages 137-137
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 139-147
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 149-154
    4. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 155-171
    5. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 173-179
  6. Reaction Rate Theory

    1. Front Matter
      Pages 181-181
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 183-186
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 187-200
    4. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 201-224
  7. Elementary Photophysics

    1. Front Matter
      Pages 225-225
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 227-236
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 237-250
    4. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 251-256
    5. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 257-267
    6. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 269-294
    7. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 295-317
  8. Elementary Photoinduced Processes

    1. Front Matter
      Pages 319-319
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 321-333
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 335-347
    4. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 349-377
    5. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 379-383
    6. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 385-393
    7. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 395-414
  9. Molecular Motor Models

    1. Front Matter
      Pages 415-415
    2. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 417-448
    3. Philipp O. J. Scherer, Sighart F. Fischer
      Pages 449-452
  10. Back Matter
    Pages 453-513

About this book

Introduction

This book gives an introduction to molecular biophysics. It starts from material properties at equilibrium related to polymers, dielectrics and membranes. Electronic spectra are developed for the understanding of elementary dynamic processes in photosynthesis including proton transfer and dynamics of molecular motors. Since the molecular structures of functional groups of bio-systems were resolved, it has become feasible to develop a theory based on the quantum theory and statistical physics with emphasis on the specifics of the high complexity of bio-systems. This introduction to molecular aspects of the field focuses on solvable models. Elementary biological processes provide as special challenge the presence of partial disorder in the structure which does not destroy the basic reproducibility of the processes. Apparently the elementary molecular processes are organized in a way to optimize the efficiency. Learning from nature by means exploring the relation between structure and function may even help to build better artificial solar cells.
The reader is exposed to basic concepts in modern biophysics, such as entropic forces, phase separation, potential of mean force, electron and proton transfer, heterogeneous reactions, coherent and incoherent energy transfer as well as molecular motors. Basic knowledge in classical and Quantum mechanics, electrostatics and statistical physics is desirable. Simplified models are presented which can be solved in limited cases analytically from the guiding lines to generate the basis for a fundamental understanding of the more complex biophysical systems. Chapters close with challenging problems whose solutions are provided at the end of the book to complete the pedagogical treatment in the book.
To the second edition several new chapters were added. The medium polarization is treated self-consistently using basic elements of polaron theory and more advanced nonlinear Schrödinger equations to describe the dynamics of solvation. Ion transport through a membrane was extended by the discussion of cooperative effects. Intramolecular transitions are now discussed in the new edition in much more detail, including also radiationless transitions. Very recent developments in spectroscopy are included, especially two-dimensional and hole-burning spectroscopy. The discussion of charge transfer processes was extended by including recent results of hole transfer in DNA in connection with the super-exchange mechanism. The chapter on molecular motors was rewritten to include the most recent developments of new models.
The book is a useful text for students and researchers wanting to go through the mathematical derivations in the theories presented. This book attracts a group of applied mathematically oriented students and scholars to the exciting field of molecular biophysics. 

Keywords

Elementary Processes in Biophysics Molecular Biophysics Explained Theoretical Biophysics textbook Molecular Biophysics Textbook Photosynthetic System Statistical Mechanics of Biopolymers Reaction Kinetics Photoinduced Processes

Authors and affiliations

  • Philipp O.J. Scherer
    • 1
  • Sighart F. Fischer
    • 2
  1. 1.Physikdepartment T38Technische Universität MünchenGarchingGermany
  2. 2.Physikdepartment T38Technische Universität MünchenGarchingGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-55671-9
  • Copyright Information Springer-Verlag GmbH Germany 2017
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-662-55670-2
  • Online ISBN 978-3-662-55671-9
  • Series Print ISSN 1618-7210
  • Series Online ISSN 2197-5647
  • Buy this book on publisher's site