Pathology and Biology of Human Germ Cell Tumors

  • Francisco F. Nogales
  • Rafael E. Jimenez

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Annalisa Trama, Franco Berrino
    Pages 11-21
  3. Ovidiu Preda, Francisco F. Nogales
    Pages 131-179
  4. Manish Kohli, Ben Y. Zhang, Brian A. Costello
    Pages 181-194
  5. Francisco F. Nogales, Maolly Schuldt
    Pages 195-266
  6. Rafael E. Jimenez, Sounak Gupta, Loren P. Herrera-Hernandez, Thomas J. Sebo
    Pages 267-325
  7. Anja C. Roden
    Pages 327-364
  8. M. Adelita Vizcaino, Fausto J. Rodriguez
    Pages 365-379
  9. Eduardo Zambrano, Danielle Vargas De Stefano, Miguel Reyes-Múgica
    Pages 381-395
  10. Alejandro Rubio-Fernández, Juan Antonio Retamero, Francisco F. Nogales
    Pages 397-417
  11. Nooshin K. Dashti, Rafael E. Jimenez
    Pages 419-439
  12. Back Matter
    Pages 441-449

About this book


This book provides, for the first time, a detailed, up-to-date, holistic approach to the pathology and biology of germ cell tumors. The main focus is the complex histopathology of these tumors, but special considerations are also given to their morphologic variations in relation to age, gender and organ. Critical updates are provided on terminology and classification; the discussion of biology and pathogenesis includes references to many molecular genetic and immunohistochemical findings from recent stem cell research. Individual chapters are devoted to germ cell tumors at different anatomic locations, including not only the ovaries and testes but also the mediastinum and central nervous system, and pediatric tumors. All of the contributing authors are opinion leaders from universities of excellence in Europe and the United States. This monograph will be of wide interest to practitioners and researchers in many fields of medicine, including pathology, gynecology, urology, and pediatrics, as well as stem cell scientists.


Germ cell tumor Differentiation Pluripotentiality Stem Cells Teratoma Mediastinum Seminoma Non seminoma Germ cell tumors Embryonal carcinoma Yolk sac tumor Choriocarcinoma Gonadal tumors Extra-gonadals germ cell tumors

Editors and affiliations

  • Francisco F. Nogales
    • 1
  • Rafael E. Jimenez
    • 2
  1. 1.Departamento de Anatomía PatológicaUniversidad de Granada Facultad de MedicinaGranadaSpain
  2. 2.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag GmbH Germany 2017
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-662-53773-2
  • Online ISBN 978-3-662-53775-6
  • Buy this book on publisher's site