Therapy of Viral Infections

1. Front Matter

   Pages i-vii

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2. HIV-1 Integrase Drug Discovery Comes of Age

   • Jonas Demeulemeester, Marc De Maeyer, Zeger Debyser

   Pages 1-52

3. Phosphonated Nucleoside Analogues as Antiviral Agents

   • Beatrice Macchi, Giovanni Romeo, Ugo Chiacchio, Caterina Frezza, Salvatore V. Giofrè, Francesca Marino-Merlo et al.

   Pages 53-91

4. Recent Advances in Targeting Dengue and West Nile Virus Proteases Using Small Molecule Inhibitors

   • Holger Steuber, Manuel Kanitz, Fabian G. R. Ehlert, Wibke E. Diederich

   Pages 93-141

5. Strategies for the Development of Influenza Drugs: Basis for New Efficient Combination Therapies

   • Torsten Steinmetzer, Kornelia Hardes, Eva Böttcher-Friebertshäuser, Wolfgang Garten

   Pages 143-181

6. Targeting Cellular Cofactors in HIV Therapy

   • Ralf Dürr, Oliver Keppler, Frauke Christ, Emmanuele Crespan, Anna Garbelli, Giovanni Maga et al.

   Pages 183-222

7. Back Matter

   Pages 223-226

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

• Dengue virus
• Drug discovery
• Inhibitor design
• West Nile virus
• viral protease

• Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany

  Wibke E. Diederich

• -, Bayer Pharma AG, Lead Discovery Berlin - Structural Biology, Berlin, Germany

  Holger Steuber

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