Vertebrate Myogenesis

Stem Cells and Precursors

  • Beate Brand-Saberi

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 56)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Karl R. Wotton, Frank R. Schubert, Susanne Dietrich
    Pages 25-48
  3. David Gurevich, Ashley Siegel, Peter D. Currie
    Pages 49-76
  4. Mordechai Applebaum, Chaya Kalcheim
    Pages 77-98
  5. Claire E. Hirst, Christophe Marcelle
    Pages 99-122
  6. Eldad Tzahor
    Pages 123-142
  7. Qin Pu, Ketan Patel, Ruijin Huang
    Pages 143-163
  8. Ning Liu, Rhonda Bassel-Duby
    Pages 165-190
  9. Ramkumar Sambasivan, Shahragim Tajbakhsh
    Pages 191-213
  10. Pierre Rocheteau, Mathilde Vinet, Fabrice Chretien
    Pages 215-235
  11. Back Matter
    Pages 237-242

About this book


This book addresses the differentiation control of skeletal muscle in different locations of the vertebrate body. Particular attention is paid to novel regulatory molecules and signals as well as to the heterogeneity of origin that have revealed a developmental overlap between skeletal and cardiac muscle. Different functional muscle groups are the product of the evolution of the vertebrate classes, making a phylogenetic comparison worthwhile for understanding the role of muscle stem cells and precursors in myogenesis. New insights into the hierarchy of transcription factors, particularly in the context of these different muscle groups come from detailed investigations of the spatio-temporal and regulatory relationships derived from mouse and zebrafish genetics and avian microsurgery. Importantly, epigenetic mechanisms that have surfaced recently, in particular the role of MyomiRs, are also surveyed.

Regarding human patients, encouraging results have been generated that identify parallels between embryonic myogenesis and regenerating myofibers  that share regulatory molecules. Interestingly, the heterogeneity in embryonic origins  of skeletal muscle groups in the vertebrate including  humans   is paralleled by their different susceptibility to types of muscle dystrophies. The progress that has been made in the field of muscle stem cell biology, especially on  satellite cells, is outlined in this book by experts in the field. The authors review recent insights of the heterogeneous nature of these satellite cells regarding their gene signatures and regeneration potential. An improved understanding of muscle stem cells seems only possible with a view to the cell environment , putting embryological and molecular findings from different vertebrate classes and stem cell approaches into context.


Cell organelles Mitochondria Organellar translation Protein biosynthesis Translation mechanisms

Editors and affiliations

  • Beate Brand-Saberi
    • 1
  1. 1.Abt. für Anatomie und Molekulare EmbryologieRuhr-Universität Bochum Medizinische FakultätBochum,Germany

Bibliographic information