Environmentally Friendly Alkylphosphonate Herbicides

  • Hong-Wu He
  • Hao Peng
  • Xiao-Song Tan

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 1-43
  3. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 45-121
  4. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 123-178
  5. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 179-219
  6. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 221-278
  7. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 279-322
  8. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 323-357
  9. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 359-390
  10. Hong-Wu He, Hao Peng, Xiao-Song Tan
    Pages 391-447
  11. Back Matter
    Pages 449-455

About this book

Introduction

This book presents essential research on a class of environmentally friendly alkylphosphonate herbicides. This class of herbicides acted as a competitive inhibitor of the pyruvate dehydrogenase complex (PDHc) to control weeds. The bioreasoning and systematic approach, from basic research to field tests of candidate compounds, are introduced. The basic research covers the molecular design, chemical synthesis, biological activities evaluation, structure-activity relationship analysis and structural optimization. Subsequently, the book reviews the biochemistry of PDHc inhibitors, the selectivity between mammals and plants, and the mechanism of herbicidal activity of novel alkylphosphonates as selective PDHc inhibitors. Field trials for selected alkylphosphonate candidates as herbicides are also included. This book provides a sound basis for the rational design and development of novel herbicides as effective PDHc inhibitors with good enzyme-selective inhibition of plant PDHc between mammals and plants. These studies take full advantages of the low toxicity and low residual impact of selective PHDc inhibitors to design an effective and environmentally friendly herbicide. This book is based on twenty years of research on alkylphosphonates and phosphorus-containing PDHc inhibitors, and demonstrates how to develop these PDHc inhibitors as an effective and “green” herbicide candidate.  

Hong-Wu He, PhD, is a Professor at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, and Director of the Institute of Pesticide Chemistry, College of Chemistry, Central China Normal University, China.
Hao Peng, PhD, and Xiao-Song Tan are both Associate Professors at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, College of Chemistry, Central China Normal University, China.

Keywords

Alkylphosphinates Alkylphosphonates Biorational design Caged Bicyclic Phosphates Clacyfos Cyclic Phosphonates Environment-friendly Herbicides Herbicidal activity PDHc inhibitor Pyruvate dehydrogenase complex

Authors and affiliations

  • Hong-Wu He
    • 1
  • Hao Peng
    • 2
  • Xiao-Song Tan
    • 3
  1. 1.College of ChemistryInstitute of Pesticide ChemistryWuhanChina
  2. 2.College of ChemistryInstitute of Pesticide ChemistryWuhanChina
  3. 3.College of ChemistryInstitute of Pesticide ChemistryWuhanChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-44431-3
  • Copyright Information Chemical Industry Press, Beijing and Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-662-44430-6
  • Online ISBN 978-3-662-44431-3
  • About this book