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The Human T-Cell Receptor Repertoire and Transplantation

  • Peter J. van den Elsen

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Peter J. van den Elsen
    Pages 1-28
  3. Linda Struyk, Gail E. Hawes, Frank Raaphorst, Marja van Eggermond, Barbara Godthelp, Peter J. van den Elsen
    Pages 29-61
  4. Gail E. Hawes, Peter J. van den Elsen
    Pages 63-84
  5. James T. Kurnick, Makiko Kumagai-Braesch, Carol P. Leary, Richard Waitkus, Lenora A. Boyle, Peter J. van den Elsen et al.
    Pages 85-100
  6. Benito A. Yard, Thomas Reterink, Peter J. van den Elsen, M. E. Paape, Jan Antony Bruijn, Leendert A. van Es et al.
    Pages 101-115
  7. Gert Datema, Len Vaessen, Rene Daane, Carla Baan, Willem Weimar, Frans Claas et al.
    Pages 117-147
  8. Benito A. Yard, Thomas Reterink, Jan Antony Bruijn, Peter J. van den Eisen, Frans J. Claas, Mohamed R. Daha et al.
    Pages 149-162
  9. Peter J. van den Eisen
    Pages 163-167
  10. Back Matter
    Pages 169-173

About this book

Introduction

these analyses it became clear that the MHC class I molecule com­ prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec­ tron-dense material in the groove. This material was subsequently iden­ 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu­ tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep­ tion of the DR a-chain, all other MHC class II a and 13 chains are poly­ morphic.

Keywords

T cell T-lymphocytes antigen cell lines complementarity determining region 3 cytotoxicity genes graft-infiltrating heart transplantation histocompatibility immunology lymphocytes major histocompatibility complex transplantation transplantation immunology

Authors and affiliations

  • Peter J. van den Elsen
    • 1
  1. 1.Department of Immunohematology and Blood BankUniversity Hospital LeidenLeidenThe Netherlands

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-22494-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22496-0
  • Online ISBN 978-3-662-22494-6
  • Series Print ISSN 1431-0414
  • Buy this book on publisher's site