Pre-mRNA Processing

  • Angus I. Lamond
  • R. G. Landes Company

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages N1-xii
  2. David M. J. Lilley
    Pages 1-15
  3. Angela Krämer
    Pages 35-64
  4. Witold Filipowicz, Marek Gniadkowski, Ueli Klahre, Hong-Xiang Liu
    Pages 65-77
  5. Juan Valcárcel, Ravinder Singh, Michael R. Green
    Pages 97-112
  6. James Scott
    Pages 151-161
  7. Maria Carmo-Fonseca, João Ferreira
    Pages 163-171
  8. Wilbert C. Boelens, Catherine Dargemont, Iain W. Mattaj
    Pages 173-186
  9. Michael Antoniou
    Pages 187-201
  10. J. Barklie Clements, Anne Phelan
    Pages 203-214
  11. Back Matter
    Pages 215-223

About this book


he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func­ tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.


Cell metabolism Protein Synthesis mRNA RNA RNA editing RNA-splicing cell gene metabolism protein protein synthesis synthesis yeast

Authors and affiliations

  • Angus I. Lamond
    • 1
  • R. G. Landes Company
    • 2
  1. 1.European Molecular Biology LaboratoryHeidelbergGermany
  2. 2.AustinUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22327-7
  • Online ISBN 978-3-662-22325-3
  • Series Print ISSN 1431-0414
  • Buy this book on publisher's site