Advertisement

Neurobiological Mechanisms of Opiate Withdrawal

  • Rafael Maldonado
  • Luis Stinus
  • George F. Koob

Part of the Neuroscience Intelligence Unit book series (NIU.LANDES)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 1-9
  3. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 11-34
  4. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 35-46
  5. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 47-76
  6. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 77-124
  7. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 125-152
  8. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 153-179
  9. Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 181-198
  10. Back Matter
    Pages 199-204

About this book

Introduction

Some general aspects of opiate dependence are described in a first section including a brief historical description and an explanation of the different models currently used to investigate opiate dependence. The neurobiological bases of opiate withdrawal are detailed in a second section, which particularly emphasizes the neurophysiological adaptative changes, the processes of homologous and heterologous regulation, and the role played by different brain structures and several endogenous peptides acting as antiopiates. The last part reports several basic aspects more directly related to the clinical perspectives of opiate dependence, such as the new expectations in the treatment of opiate withdrawal or the relationships between sensitization, tolerance and withdrawal.

Keywords

brain cellular immune response humoral immune response lymphocytes metabolic processes metabolism neurochemistry neurophysiology nitric oxide synthesis pharmacology physiology psychopharmacology trauma tumor tumor metabolism

Authors and affiliations

  • Rafael Maldonado
    • 1
  • Luis Stinus
    • 2
  • George F. Koob
    • 3
  1. 1.Pharmacochimie Moléculaire et StructuraleParisFrance
  2. 2.Université de Bordeaux IIBordeaux CédexFrance
  3. 3.The Scripps Research InstituteLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-22218-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22220-1
  • Online ISBN 978-3-662-22218-8
  • Series Print ISSN 1431-0406
  • Buy this book on publisher's site