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Neural Transplantation in Cerebellar Ataxia

  • Lazaros C. Triarhou

Part of the Neuroscience Intelligence Unit book series (NIU.LANDES)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Lazaros C. Triarhou
    Pages 1-3
  3. Lazaros C. Triarhou
    Pages 5-29
  4. Lazaros C. Triarhou
    Pages 31-43
  5. Lazaros C. Triarhou
    Pages 45-79
  6. Lazaros C. Triarhou
    Pages 95-112
  7. Lazaros C. Triarhou
    Pages 131-148
  8. Lazaros C. Triarhou
    Pages 149-158
  9. Back Matter
    Pages 159-162

About this book

Introduction

erebellar ataxia is a failure in muscular coordination that re­ C sults from a slow, progressive deterioration of neurons in the cerebellum. An estimated 150,000 people are affected by the he­ reditary ataxias and related disorders in the United States. At present, there is no known cure. In an experimental treatment aimed at reconstructing the damaged pathway through exog­ enous neuronal supplementation, genetically ataxic mice have been used for intracerebral grafting of genetically healthy cerebellar neuroblasts, and evidence has been obtained for graft-induced en­ hancement of behavioral responses after bilateral cerebellar grafts. Such results are encouraging and underscore the potential of the neural grafting technique in restoring cerebellar function. How­ ever, many of the pathological and biochemical mechanisms in the interaction between grafted tissue and the host brain need to be further elucidated in extensive experimental studies, and great cau­ tion must be used in contemplating the theoretical feasibility of a possible application in humans.

Keywords

experiment health neurobiology research

Authors and affiliations

  • Lazaros C. Triarhou
    • 1
  1. 1.Indiana University School of MedicineIndianapolisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-22213-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22215-7
  • Online ISBN 978-3-662-22213-3
  • Series Print ISSN 1431-0406
  • Buy this book on publisher's site