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Intracellular Signal Transduction: The JAK-STAT Pathway

  • Andrew F. Wilks
  • Ailsa G. Harpur

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Andrew F. Wilks, Ailsa G. Harpur
    Pages 1-22
  3. Andrew F. Wilks, Ailsa G. Harpur
    Pages 23-43
  4. Andrew F. Wilks, Ailsa G. Harpur
    Pages 45-61
  5. Andrew F. Wilks, Ailsa G. Harpur
    Pages 63-77
  6. Andrew F. Wilks, Ailsa G. Harpur
    Pages 79-91
  7. Andrew F. Wilks, Ailsa G. Harpur
    Pages 105-132
  8. Andrew F. Wilks, Ailsa G. Harpur
    Pages 153-167
  9. Back Matter
    Pages 169-209

About this book

Introduction

This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.

Keywords

Drosophila cytokine protein receptor signal transduction transcription

Authors and affiliations

  • Andrew F. Wilks
    • 1
  • Ailsa G. Harpur
    • 1
  1. 1.Ludwig Institute for Cancer ResearchMelbourneAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-22050-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22052-8
  • Online ISBN 978-3-662-22050-4
  • Series Print ISSN 1431-0414
  • Buy this book on publisher's site