Human Hematopoiesis in SCID Mice

  • Maria-Grazia Roncarolo
  • Bruno Péault
  • Reiko Namikawa

Part of the Medical Intelligence Unit book series (MIU.LANDES)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Human Hematopoietic Development

    1. Front Matter
      Pages 1-1
    2. Anne H. M. Galy, Benjamin P. Chen
      Pages 15-34
    3. Maria-Grazia Roncarolo, Dominique Schols, Reiko Namikawa, Jan E. de Vries
      Pages 35-52
    4. Marcus O. Muench, Maria-Grazia Roncarolo, Reiko Namikawa
      Pages 53-68
  3. Human Immune Responses

    1. Front Matter
      Pages 69-69
    2. Mohammad R. Abedi, Lennart Hammarström, Birger Christensson, C. I. Edvard Smith
      Pages 71-103
  4. Models for Human Hematopoietic Diseases

    1. Front Matter
      Pages 127-127
    2. Joseph M. Mccune, Hideto Kaneshima
      Pages 129-156
    3. Alessandra Cesano, Daniela Santoli
      Pages 171-196
    4. Josef Vormoor, Tsvee Lapidot, André Larochelle, John E. Dick
      Pages 197-212
  5. Back Matter
    Pages 213-225

About this book


This book presents essential information on the use of the immunodeficient C.B.-17 SCID/SCID mouse for studying human hematopoiesis in vivo. Because of the lack of both humoral and cellular immunity, this mouse can be a unique host for implantation of human hematopoietic tissue using different methods. In the first section, in vivo development of human hematopoietic stem cells and differentiation of human T cells are described. In addition, the effects of growth factors and toxic agents of human hematopoiesis are described. The second section contains chapters in which the human immune responses in the SCID mouse are reviewed. The third section covers SCID mouse models to study human infectious diseases, leukemias and genetic disorders.


HIV antigen cytokine diseases growth factor hematopoiesis hematopoietic stem cell humoral immunity immune response immunity infectious disease leukemia pathology stem cells tissue

Authors and affiliations

  • Maria-Grazia Roncarolo
    • 1
  • Bruno Péault
    • 2
  • Reiko Namikawa
    • 1
  1. 1.DNAX Research Institute of Molecular and Cellular BiologyPalo AltoUSA
  2. 2.Institut d’Embryologie Cellulaire et Moléculaire du CNRS et du Collège de FranceNogent-sur-MarneFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-22010-8
  • Online ISBN 978-3-662-22008-5
  • Series Print ISSN 1080-3645
  • Buy this book on publisher's site