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Mitochondrial DNA Mutations in Aging, Disease and Cancer

  • Keshav K. Singh

Table of contents

  1. Front Matter
    Pages i-xx
  2. Dongchon Kang, Koichiro Takeshige, Mutsuo Sekiguchi, Keshav K. Singh
    Pages 1-15
  3. Howard T. Jacobs, Ian J. Holt
    Pages 43-83
  4. C. William Birky Jr.
    Pages 85-99
  5. Kylie F. Keshav, Shonen Yoshida
    Pages 101-114
  6. Lene Juel Rasmussen, Keshav K. Singh
    Pages 115-127
  7. T. B. L. Kirkwood, A. Kowald
    Pages 129-145
  8. Patrice X. Petit, Guido Kroemer
    Pages 147-165
  9. Carlos T. Moraes
    Pages 167-184
  10. Brian H. Robinson
    Pages 185-204
  11. Phillip Nagley, Chunfang Zhang
    Pages 205-238
  12. Takayuki Ozawa, Mika Hayakawa
    Pages 239-263
  13. Michael Lin, M. Flint Beal
    Pages 265-296
  14. Brian Bandy, Allan J. Davison
    Pages 319-336
  15. Josephine S. Modica-Napolitano
    Pages 337-344
  16. K. M. A. Welch, Charles Flippen
    Pages 383-394
  17. Peter Seibel, Adrian Flierl, Corinna Bachmann, Martina Seibel
    Pages 395-402
  18. Back Matter
    Pages 403-412

About this book

Introduction

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

Keywords

Alzheimer Krankheit Alzheimer's disease DNA Huntington's diesease Huntington-Krankheit Mitochondrien Onkology Parkinson's disease Parkinsonsche Krankheit aging apoptosis cancer cell death mitochondria oncology

Editors and affiliations

  • Keshav K. Singh
    • 1
  1. 1.The Division of Experimental Therapeutics and Radiation Oncology, Johns Hopkins Oncology Center and Department of Environmental HealthJohns Hopkins School of Public HealthBaltimoreUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-12509-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-12511-3
  • Online ISBN 978-3-662-12509-0
  • Buy this book on publisher's site