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Cardiac Glycosides 1785–1985

Biochemistry — Pharmacology — Clinical Relevance

  • Erland Erdmann
  • K. Greef
  • J. C. Skou

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Historial aspects

  3. Cardiac glycosides, (Na+ + K+)-ATPase and cation transport

    1. E. T. Wallick, T. L. Kirley, A. Schwartz
      Pages 27-33
    2. D. A. Eisner, M. Valdeolmillos, W. J. Lederer, M. B. Cannell
      Pages 69-78
    3. L. G. Lelièvre, J. M. Maixent, D. Charlemagne, B. Swynghedauw
      Pages 87-92
    4. D. Charlemagne, E. Mayoux, M. Preteseille, J. M. Maixent, Ch. Mouas, B. Swynghedauw et al.
      Pages 93-98
    5. G. Grupp, Ingrid L. Grupp, T. Hickerson, S. W. Lee, A. Schwartz
      Pages 99-108
  4. Digitalis-like substances

    1. W. Schoner, K. Moreth, R. Kuske, D. Renner
      Pages 135-142
    2. S. Vasdev, L. Longerich, E. Johnson, D. Brent, M. H. Gault
      Pages 157-164
    3. M. Krekler, A. A. L. Fox, H. Strobach, K. Greeff
      Pages 165-169
    4. G. Scholtysik, H. Wagner, M. Fischer, U. Rüegg
      Pages 171-179
  5. Mechanism of inotropic effects — cardiac glycosides and other positive inotropic agents

  6. Cardiac glycosides — metabolism, interactions and volume of distribution

    1. K. E. Wirth
      Pages 257-262
    2. J. Lindenbaum
      Pages 263-268
    3. A. Schmoldt, L. von Meyerinck, W. Drohn, I. Blömer
      Pages 273-279
    4. Kathryn A. Taubert, C. Bufalino, T. Hair, C. Lafleur
      Pages 281-286
    5. E. Petzinger, K. Fischer, H. Fasold
      Pages 297-304
    6. J. Plum, T. Daldrup, B. Grabensee, H. Schweitzer
      Pages 305-313
    7. K.-O. Haustein, Elke Bucha, W.-D. Schlott, G. Hüller, G. Oltmanns
      Pages 323-328
    8. J. J. H. M. Lohman, P. M. Hooymans, M. L. P. Koten, F. W. H. M. Merkus
      Pages 329-335
    9. Tomas Jogestrand, K. Andersson, R. Dahlqvist, T. Joreteg
      Pages 337-342
  7. Extracardiac effects of cardiac glycosides

About these proceedings

Introduction

The bicentenary of William Withering's now famous medical report entitled "An Account of the Foxglove and Some of its Medical Uses" has given us the occasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure with sinus rhythm has never ceased. Although cardiac glycosides are of unquestionable value in tachycardia caused by atrial fibrillation or atrial flutter, the chronic use of these drugs in sinus rhythm is not generally accepted. The development of tolerance has been reported. It is of interest that Withering hirnself wrote: "-let it (foxglove) be continued until it either acts on the kidneys, the stomach, the pulse, or the bowels; Iet it be stopped upon the first appearance of any of these effects, and I will maintain that the patient will not suffer from its exhibition, nor the practitioner be disappointed in any reasonable expectation. " In West Germany alone, more than three million patients (about 5% of the total population) are constantly taking cardiac glycosides. These drugs are the most prescribed medicaments in many countries. Thus, we considered it worthwhile and necessary to review in a critical way today's knowledge about the foxglove; to report new findings and to evaluate old Statements.

Keywords

anesthesia artery atrial fibrillation drugs electrocardiogram (ECG) heart heart disease heart failure myocardial infarction pharmacodynamics physiology

Editors and affiliations

  • Erland Erdmann
    • 1
  • K. Greef
    • 2
  • J. C. Skou
    • 3
  1. 1.Medizinische Klinik IKlinikum Großhadern der Universität MünchenMünchen 70West Germany
  2. 2.Institut für PharmakologieUniversität DüsseldorfDüsseldorfWest Germany
  3. 3.Biophysik InstitutAarhus UniversitetAarhusDenmark

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-11292-2
  • Copyright Information Steinkopff-Verlag Darmstadt 1986
  • Publisher Name Steinkopff, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-11294-6
  • Online ISBN 978-3-662-11292-2
  • Buy this book on publisher's site