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The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System

  • Georg Gosztonyi

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 253)

Table of contents

  1. Front Matter
    Pages I-IX
  2. J. K. Fazakerley, T. E. Allsopp
    Pages 95-119
  3. B. Dietzschold, K. Morimoto, D. C. Hooper
    Pages 145-155
  4. M. Hornig, M. Solbrig, N. Horscroft, H. Weissenböck, W. I. Lipkin
    Pages 157-177
  5. V. J. Sanders, C. A. Wiley, R. L. Hamilton
    Pages 179-201
  6. P. J. Talbot, D. Arnold, J. P. Antel
    Pages 247-271
  7. Back Matter
    Pages 273-280

About this book

Introduction

It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.

Keywords

Nervous System apoptosis autoimmune disease cell infection infections inflammation neurons programmed cell death protein proteins receptor retroviruses virology virus

Editors and affiliations

  • Georg Gosztonyi
    • 1
  1. 1.Universitätsklinikum Benjamin Franklin Abt. für NeuropathologieFU Berlin, Fachbereich HumanmedizinBerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-10356-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-08710-3
  • Online ISBN 978-3-662-10356-2
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site