Cell Immortalization

  • Alvaro¬†Macieira-Coelho

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 24)

Table of contents

  1. Front Matter
    Pages I-VII
  2. C. Bernstein, H. Bernstein, C. Payne
    Pages 23-50
  3. A. Macieira-Coelho
    Pages 51-80
  4. H. L. Ozer
    Pages 121-153
  5. K. Perrem, R. R. Reddel
    Pages 173-189
  6. Back Matter
    Pages 205-207

About this book


This book describes the most outstanding theoretical hypotheses aiming at explaining the infinite proliferative potential of a cell population, what is now known under the term cell immortalization. It elucidates the phenomenon from an evolutionary point of view, and describes the cell systems used and the experiments performed at the cellular and molecular levels to determine the mechanisms responsible for this cell property. It also appraises how the mortal and immortal phenotypes reflect characteristics of the respective organism, and stresses how this goes beyond the proposal that its opposite, the mortal phenotype, is a mechanism to protect the organism against cancer.


Cell immortalization Krebs Seneszenz aging biology cancer cell cell division evolution gene mortality senescence

Editors and affiliations

  • Alvaro¬†Macieira-Coelho
    • 1
  1. 1.INSERMVersaillesFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-08491-1
  • Online ISBN 978-3-662-06227-2
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site