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Clinical and Diagnostic Pathology of Graft-versus-Host Disease

  • Berno Heymer

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Berno Heymer
    Pages 1-3
  3. Berno Heymer
    Pages 5-11
  4. Berno Heymer
    Pages 13-26
  5. Berno Heymer
    Pages 27-40
  6. Berno Heymer
    Pages 103-121
  7. Berno Heymer
    Pages 123-125
  8. Berno Heymer
    Pages 127-128
  9. Back Matter
    Pages 129-156

About this book

Introduction

Graft-versus-host Disease (GvHD) occurs primarily but not exclusively as a complication in the context of allogeneic bone marrow or peripheral blood stem cell transplantation (BMT or PBSCT), the treatment of choice for various life-threatening diseases. GvHD may affect skin, liver, gut, and other organs and sometimes runs a devastating or even lethal course. The diagnosis of GvHD is based on both clinical and histomorphological parameters. However, due to the widespread use of GvHD prophylaxis in patients undergoing allogeneic BMT or PBSCT, the number of histologically typical lesions has decreased, while the number of atypical, low-grade or masked lesions has increased. Therefore, an update of the clinical and diagnostic pathology of GvHD of skin, liver, gastrointestinal tract and other organs is required. In the present volume the histological features of GvHD lesions under today's conditions are described and illustrated in detail. Particular emphasis is placed on differential diagnostic problems and histodiagnostic pitfalls. Finally, the applicability and limits of immunohistological methods for the diagnosis of GvHD are shown.

Keywords

Alloimmune Reacation Bone Marrow Transplantation Fatigue Graft-versus-Host Disease Hematology Hematopathology Hematopoietic Stem Cell Stem Cell Transplantation

Authors and affiliations

  • Berno Heymer
    • 1
  1. 1.Abteilung PathologieUniversität UlmUlmGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-04715-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-08721-9
  • Online ISBN 978-3-662-04715-6
  • Buy this book on publisher's site