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The Interface Between Innate and Acquired Immunity

  • Max D. Cooper
  • Hilary Koprowski

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 266)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. L. Moretta, R. Biassoni, C. Bottino, M. C. Mingari, A. Moretta
    Pages 11-22
  3. V. L. Heath, H. Kurata, H. J. Lee, N. Arai, A. O’Garra
    Pages 23-39
  4. R. S. Davis, G. Dennis Jr., H. Kubagawa, M. D. Cooper
    Pages 85-112
  5. Back Matter
    Pages 113-118

About this book

Introduction

All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de­ fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy­ totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen­ specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present­ ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re­ sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.

Keywords

Antigen NK cells T cell T helper cells antigen-specific receptor genes autoimmune disease genes histocompatibility immunity necrosis phylogeny protein virus

Editors and affiliations

  • Max D. Cooper
    • 1
  • Hilary Koprowski
    • 2
  1. 1.Howard Hughes Medical Institute Research LaboratoriesUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Microbiology and Immunology Center for Neurobiology, Jefferson Alumni HallJefferson Medical CollegePhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-04700-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-07682-4
  • Online ISBN 978-3-662-04700-2
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site