Neurodegenerative Disorders: Loss of Function Through Gain of Function

  • Konrad Beyreuther
  • Yves Christen
  • Colin L. Masters
Conference proceedings

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. T. L. Williamson, D. W. Cleveland
    Pages 23-40
  3. A. Lunkes, G. Yvert, Y. Trottier, D. Devys, J. L. Mandel
    Pages 41-53
  4. V. R. Lingappa, R. S. Hegde
    Pages 55-66
  5. D. L. Price, P. C. Wong, A. L. Markowska, G. Thinakaran, M. K. Lee, L. J. Martin et al.
    Pages 67-86
  6. M. Jucker, M. Calhoun, A. Phinney, M. Stalder, L. Bondolfi, D. Winkler et al.
    Pages 87-95
  7. R. Kopan, S. Huppert, J. S. Mumm, M. T. Saxena, E. H. Schroeter, W. J. Ray et al.
    Pages 119-128
  8. B. De Strooper, A. Herreman, P. Cupers, K. Craessaerts, L. Serneels, W. Annaert
    Pages 129-140
  9. B. Allinquant, G. Mainguy, A. Prochiantz
    Pages 149-158
  10. Back Matter
    Pages 187-189

About these proceedings


A fundamental change is occurring in the understanding of the major neurodegenerative disorders. Protein aggregation is a common emerging theme in diseases as diverse as Alzheimer's, Creutzfeld-Jakob, Parkinson's, and amyotrophic lateral sclerosis. If valid, then a small number of diagnostic and rational therapeutic strategies will emerge over the next few years, based on the common theme of modulation of the production, turnover and deposition of these aggregating proteins. The book provides insights into the cellular and animal models of these diseases, and how the molecular basis of neurodegeneration has become the preferred target of therapy.


Alzheimer Alzheimer's Disease Huntingdon's Disease amyloid precursor protein amyotrophic lateral sclerosis cerebral amyloidosis presenilin transgenic models

Editors and affiliations

  • Konrad Beyreuther
    • 1
  • Yves Christen
    • 2
  • Colin L. Masters
    • 3
  1. 1.ZMBHUniversity of HeidelbergHeidelbergGermany
  2. 2.Pour la Recherche ThérapeutiqueFondation IPSENParis Cedex 16France
  3. 3.Department of Pathology and The Mental Health Institute of VictoriaThe University of MelbourneParkvilleAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-07448-6
  • Online ISBN 978-3-662-04399-8
  • Series Print ISSN 0945-6066
  • Series Online ISSN 2196-310X
  • Buy this book on publisher's site