Advertisement

EGF Receptor in Tumor Growth and Progression

  • R. B. Lichtner
  • R. N. Harkins

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 19)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. R. B. Lichtner, R. N. Harkins
    Pages 1-17
  3. K. Elenius, G. Allison, S. K. Das, B. C. Paria, S. K. Dey, M. Klagsbrun
    Pages 45-64
  4. R. I. Nicholson, J. M. W. Gee, H. Jones, M. E. Harper, A. E. Wakeling, P. Willsher et al.
    Pages 105-128
  5. R. I. Yarden, M. A. Wilson, M. Barth, S. A. Chrysogelos
    Pages 129-154
  6. F. Radvanyi, S. Bellusci, B. Boyer, J. Jouanneau, P. Savagner, A. M. Vallés et al.
    Pages 155-164
  7. W. Wels, M. Schmidt, M. Jeschke, B. Groner, R. R. Beerli, N. E. Hynes et al.
    Pages 211-232
  8. J. Mendelsohn, J. Baselga, X. Wu, D. Peng, C. Brown, J. L. Chou et al.
    Pages 233-251
  9. Back Matter
    Pages 253-258

About these proceedings

Introduction

Members of the tyrosine kinase family are frequently implicated in experimental as well as in human cancer. The best studied receptor signaling system from this family is the EGF receptor. Experts in this area report on the involvement of the receptor in a variety of human tumors, outline underlying molecular mechanisms for aberrant receptor signaling in experimental systems and present the status of current therapies directed against the receptor. A detailed analysis of EGF receptor signal transduction via expression of receptor, ligands, phosphatases and presence of other members of the receptor family will provide new information for the design of therapeutic modalities targeting this receptor system.

Keywords

EGF Receptor EGF Rezeptor Signal Transduction Signaltransduktion Tyrosinkinase angiogenesis antibody breast cancer cancer cancer therapy growth factor tumor tumor growth tumor progression tumorigenesis

Editors and affiliations

  • R. B. Lichtner
    • 1
  • R. N. Harkins
    • 2
  1. 1.Research Laboratories of Schering AGExperimental OncologyBerlinGermany
  2. 2.Berlex BiosciencesProtein Biochemistry and BiophysicsRichmondUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-03391-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-03393-7
  • Online ISBN 978-3-662-03391-3
  • Series Print ISSN 0947-6075
  • Buy this book on publisher's site