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Nongenotoxic Carcinogenesis

  • Editors
  • Andrew Cockburn
  • Lewis Smith
Conference proceedings

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 10)

Table of contents

  1. Front Matter
    Pages I-XII
  2. P. Amstad, R. Ghosh, G. Shah, Y. Oya, P. Cerutti
    Pages 17-29
  3. R. Schulte-Hermann, W. Bursch, B. Grasl-Kraupp, W. Huber, W. Parzefall
    Pages 109-120
  4. A. Balmain, C. J. Kemp, P. A. Burns, R. Bremner, S. Bryson, M. Clarke et al.
    Pages 141-156
  5. C. L. Berry
    Pages 231-238
  6. Back Matter
    Pages 239-240

About these proceedings

Introduction

"What is a nongenotoxic carcinogen?" This question recurred through­ out the Ernst Schering Research Foundation Workshop on nongeno­ toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin­ ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in­ crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl­ edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci­ nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com­ mon mechanisms include hormonal imbalance resulting in thyroid tu­ mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book.

Keywords

DNA Hormone breast cancer cancer carcinogenesis cell hormones kidney liver liver tumor prevention toxicity transcription tumor

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-03022-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1994
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-03024-0
  • Online ISBN 978-3-662-03022-6
  • Series Print ISSN 0947-6075
  • Buy this book on publisher's site