Advertisement

Modelling Proteasome Dynamics in a Bayesian Framework

  • Sabine Stübler

Part of the BestMasters book series (BEST)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Sabine Stübler
    Pages 17-32
  3. Sabine Stübler
    Pages 33-54
  4. Sabine Stübler
    Pages 55-93
  5. Sabine Stübler
    Pages 95-105
  6. Back Matter
    Pages 107-112

About this book

Introduction

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

Contents
  • Structure and Function of the Proteasome
  • Approaches to Model Proteasome Dynamics
  • Comparison of the Dynamics of Proteasome Subtypes
  • Inhibitor Influence on the Catalytic Subunits 
  • Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model 
Target Groups
  • Lecturers and students of systems biology, immunology and cell biology
  • Practitioners from the fields of systems biology, immunology and cell biology
About the Author
Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Keywords

Approximate Bayesian Computation ODE Model Thymoproteasome Immunoproteasome Proteaseome inhibitor Enzyme kinetics Modelling Proteasome Dynamics in a Bayesian Framework

Authors and affiliations

  • Sabine Stübler
    • 1
  1. 1.Institute of Biochemistry and BiologyUniversity of PotsdamPotsdamGermany

Bibliographic information