Towards Offline PET Monitoring at a Cyclotron-Based Proton Therapy Facility

Experiments and Monte Carlo Simulations

  • Matthias Würl

Part of the BestMasters book series (BEST)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Matthias Würl
    Pages 1-4
  3. Matthias Würl
    Pages 39-75
  4. Matthias Würl
    Pages 77-79
  5. Back Matter
    Pages 81-86

About this book


Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.


  • Monte Carlo Modeling of a Clinical Proton Beam
  • Low-Dose Envelope and Field Size Factor
  • PET Activation Studies

Target Groups

  • Researchers and students in the field of medical physics with focus on particle therapy
  • Medical physicists at proton therapy facilities

The Author

Matthias Würl wrote his Master’s Thesis at the chair of Medical Physics at the Ludwig-Maximilians University Munich. He is now a PhD student at the same department, working on transmission imaging with laser-accelerated ions.


Clinical Proton Beam Low-Dose Envelope Field Size Factor Particle Therapy PET Measurement

Authors and affiliations

  • Matthias Würl
    • 1
  1. 1.LMU MünchenGarchingGermany

Bibliographic information