3D Analysis of the Myocardial Microstructure

Determination of Fiber and Sheet Orientations

  • Johanna Maria Ticar

Part of the BestMasters book series (BEST)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Johanna Maria Ticar
    Pages 1-6
  3. Johanna Maria Ticar
    Pages 7-27
  4. Johanna Maria Ticar
    Pages 29-59
  5. Johanna Maria Ticar
    Pages 61-72
  6. Back Matter
    Pages 73-76

About this book


The master thesis of Johanna Maria Ticar reveals high-resolution insights into the myocardial microstructure and illustrates that cardiac muscle fibers are straight, running in parallel with one preferred fiber direction, however, deposits such as fat seem to compromise the regular and compact structure. Second harmonic generation imaging combined with optical tissue clearing is an accurate method for determining the three-dimensional muscle fiber and sheet orientations and hence, allows the calculation of fiber rotation throughout the ventricle wall.


 Structure of the Human Myocardium
 Imaging Tools for Fiber Mapping
 Optical Tissue Clearing
 Second Harmonic Generation Imaging
 3D Reconstruction and Visualization

Target Groups

 Researchers and Students in the field of Biomedical Engineering with a focus on Bioengineering and Biomechanics
 Professionals in the field of Biomedicine

The Author

Johanna Maria Ticar, MSc, studied Biomedical Engineering at Graz University of Technology. Her research interests are the microstructure of the human body, tissue engineering and regenerative medicine, foremost in the field of cardiology.


Microstructure Second Harmonic Generation Imaging Optical Tissue Clearing Fiber Orientation Cardiac Muscle Fibers

Authors and affiliations

  • Johanna Maria Ticar
    • 1
  1. 1.GrazAustria

Bibliographic information

  • DOI
  • Copyright Information Springer Fachmedien Wiesbaden 2016
  • Publisher Name Springer Spektrum, Wiesbaden
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-658-11423-7
  • Online ISBN 978-3-658-11424-4
  • Buy this book on publisher's site