Table of contents

  1. Front Matter
    Pages I-XVII
  2. Principles of Fibrin Sealing

  3. General Surgery and Abdominal Surgery

    1. Front Matter
      Pages 61-61
    2. S. Karácsonyi, G. Farkas, M. Karácsonyi, H. Bajusz, T. Oláh
      Pages 85-90
    3. R. A. F. Gonzaga, J. T. Amarante, V. Saleiro, H. M. Costa, S. R. Carneiro, J. C. Reis et al.
      Pages 116-121
    4. H. Alessandrini, A. Pineschi, A. Giannotta
      Pages 131-139
    5. G. Romeo, F. Basile, G. Giannone, A. Iuppa, L. Sandonato, O. E. Chiarenza
      Pages 152-154
    6. R. Giardino, M. Brulatti, A. Franchini
      Pages 155-158
    7. A. Zehle, A. Welz
      Pages 159-164
    8. M. Jung, M. Raute, B. C. Manegold
      Pages 173-179
    9. H. Köstering, J. U. Wieding, J. Graudins, G. Eisinger, J. Kussmann, J.-H. Beyer
      Pages 184-193
    10. R. Pointner, J. Kofler, Ch. Offer, G. Schwab
      Pages 194-198
  4. Back Matter
    Pages 203-204

About these proceedings


Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage, and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation. The concept of using clotting substances from human blood for wound manage­ ment and to achieve hemostasis in bleeding parenchymatous organs can be traced to 1909, when Bergel [1] reported on the hemostatic effect of fibrin powder. In 1915, Grey [3] employed fibrin to control bleeding in neurosurgical operations of the brain. A year later, Harvey [4] used fibrin patches to stop bleeding from parenchy­ matous organs in general surgery. It took more than two decades for this ingenious idea to be rediscovered. In 1940, Young and Medawar [8] reported on experimental nerve anastomosis by sealing. Similarly, Tarlov and Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov improved the results obtained with clot anastomosing of nerves by avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2] reported on an initial series of eight cases in which fibrinogen and thrombin had been used successfully for anchoring skin grafts.


abdominal surgery blood brain colorectal surgery endoscopy general surgery liver medicine plasma proliferation skin surgery thoracic surgery transplantation tumor

Editors and affiliations

  • Günther Schlag
    • 1
  • Heinz Redl
    • 1
  1. 1.Ludwig-Boltzmann-Institut für experimentelle TraumatologieViennaAustria

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-17280-2
  • Online ISBN 978-3-642-95513-6
  • Buy this book on publisher's site