Nucleic Acids in Immunology

Proceedings of a Symposium Held at the Institute of Microbiology of Rutgers, The State University

  • Otto J. Plescia
  • Werner Braun
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Oligo- and Polynucleotides as Haptens (Part I)

    1. Front Matter
      Pages 1-1
    2. Michael Heidelberger
      Pages 3-4
    3. Otto J. Plescia, Werner Braun, Saverio Imperato, Elisa Cora-Block, Lydie Jaroskova, Connie Schimbor
      Pages 5-17
    4. A. J. Garro, B. F. Erlanger, S. M. Beiser
      Pages 47-57
  3. Oligo- and Polynucleotides as Haptens (Part II)

    1. Front Matter
      Pages 77-77
    2. P. Grabar, S. Avrameas, B. Taudou, J. C. Salomon
      Pages 79-87
    3. Sergio Estrada-Parra, Eugenia Olguin-Palacios
      Pages 88-97
    4. M. Seligmann, R. Arana
      Pages 98-113
  4. Use of Nucleic Acid-Specific Antibodies

  5. Role of the Carrier in the Production of Hapten-Specific Antibodies

    1. Front Matter
      Pages 275-275
    2. Ira Green, Bernard B. Levine, William E. Paul, Baruj Benacerraf
      Pages 288-300
    3. O. J. Plescia, C. V. Rao, S. Curtis, V. Johnson, H. Noltenius
      Pages 319-329
    4. Thomas J. Gill III, David S. Papermaster, Heinz W. Kunz, Peter S. Marfey
      Pages 330-337
  6. Nucleic Acids as Non-Specific Stimulators of Immune Responses

    1. Front Matter
      Pages 345-345
    2. Werner Braun, Masayasu Nakano, Lydie Jaraskova, Yukiyoshi Yajima, Luis Jimenez
      Pages 347-363
    3. A. G. Johnson, J. Schmidtke, K. Merritt, I. Han
      Pages 379-385
  7. Role of Nucleic Acids in Specific Antibody Formation (Part I)

    1. Front Matter
      Pages 437-437
    2. M. Fishman, F. L. Adler, M. Holub
      Pages 439-446
    3. Abram B. Stavitsky
      Pages 447-470
    4. A. Arthur Gottlieb
      Pages 471-486
    5. P. Alexander, E. J. Delorme, L. D. Hamilton, J. G. Hall
      Pages 527-534
  8. Role of Nucleic Acids in Specific Antibody Formation

About these proceedings


Two fields have played a leading role in biomedical research in recent years, the biochemistry of nucleic acids and immunology. Yet, with the exception of those aspects which have been concerned with antibody synthesis as an example of protein synthesis, there was until recently a lack of direct association between the two fields. Until quite recently the antigenicity of nucleic acids was still in doubt and indeed represented a controversial subject. Also, the exact role of the various nucleic acids in various stages of antibody synthesis was uncertain. These skepticisms and uncertainties disappeared rapidly in the last few years. New experi­ mental approaches brought the realization that nucleic acids, under appropriate conditions, are indeed immunogenic, and that the resulting antibodies can furnish new tools for the exploration of the mplecular structure of the all-important family of nucleic acid molecules. ' At the same time, the recognition of the antigenicity of nucleic acids brought a new level of understanding to certain auto-immune diseases and pro­ vided new material for the exploration of the role of a carrier in immune responses. Side by side with this development was the almost explosive development of new experimental approaches and new ideas pertaining to the problem of antibody formation. Nucleic acids in their various forms were recognized as playing an expected major role in the activation of antibody-forming cells. Perhaps less to be expected was the role they can playas non-specific stimulators of antibody formation.


Antigen biochemistry biomedical research chemistry diseases immune response immunology protein

Editors and affiliations

  • Otto J. Plescia
    • 1
  • Werner Braun
    • 1
  1. 1.Institute of MicrobiologyRutgers, The State UniversityUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1968
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-87670-7
  • Online ISBN 978-3-642-87668-4
  • Buy this book on publisher's site