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Immunological Aspects of Viral Oncolysis

  • Jean Lindenmann
  • Paul A. Klein

Table of contents

  1. Front Matter
    Pages i-vi
  2. Jean Lindenmann, Paul A. Klein
    Pages 1-3
  3. Jean Lindenmann, Paul A. Klein
    Pages 3-9
  4. Jean Lindenmann, Paul A. Klein
    Pages 9-13
  5. Jean Lindenmann, Paul A. Klein
    Pages 13-18
  6. Jean Lindenmann, Paul A. Klein
    Pages 18-66
  7. Jean Lindenmann, Paul A. Klein
    Pages 66-75
  8. Jean Lindenmann, Paul A. Klein
    Pages 75-75
  9. Back Matter
    Pages 75-86

About this book

Introduction

mouse tissue alloantigen detected by this procedure. An antigen of cross-reacting specificity was revealed in tissue extracts of many other animal species. We next wanted to learn more about the antigen responsible for induction of postoncolytic immunity. Extracts from virus-infected tumors were immunogenic, and both active and inactive fractions of such extracts were obtained. The growth of the virus in the tumor cells was studied with the electron microscope, in the hope that this might shed some light on the manner in which viral infection transforms a poorly immunogenic tumor into a highly immunogenic one. We consider none of the questions which our work has raised as definitely solved. In fact, we are still working on many of the aspects alluded to above. When we embarked on a study of postoncolytic immunity, we were supported in this endeavor by our lack of experience in the fields of transplantation and tumor immunology.

Keywords

growth immunology neoplasm transplantation tumor virus

Authors and affiliations

  • Jean Lindenmann
    • 1
  • Paul A. Klein
    • 2
  1. 1.Institute for Medical MicrobiologyThe University of ZurichSwitzerland
  2. 2.Department of Microbiology, College of MedicineUniversity of FloridaGainesvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-87044-6
  • Copyright Information Springer-Verlag Berlin · Heidelberg 1967
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-87046-0
  • Online ISBN 978-3-642-87044-6
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • Buy this book on publisher's site