Antiarrhythmic Drugs

Mechanisms of Antiarrhythmic and Proarrhythmic Actions

  • Günter Breithardt
  • Martin Borggrefe
  • A. John Camm
  • Mohammad Shenasa
  • Wilhelm Haverkamp
  • Gerhard Hindricks

Table of contents

  1. Front Matter
    Pages I-XII
  2. Basic Mechanisms of Antiarrhythmic Drug Action

  3. Modulation of Antiarrhythmic Drug Action by Disease and Injury

    1. Front Matter
      Pages 107-107
    2. K. S. Ginsburg, M. F. Arnsdorf
      Pages 109-121
    3. M. Borggrefe, W. Haverkamp, A. Martinez-Rubio, T. Wichter, G. Breithardt
      Pages 122-143
    4. G. Breithardt, W. Haverkamp, B. Rotman, S. Willems, G. Hindricks, M. Shenasa et al.
      Pages 144-170
  4. Reentrant Excitation: Pharmacological Interactions

    1. Front Matter
      Pages 171-171
    2. L. Boersma, J. Brugada, M. Allessie
      Pages 173-191
  5. Variability of the Arrhythmogenic Substrate: Drug Influences

  6. “Novel” Antiarrhythmic Drugs

    1. Front Matter
      Pages 333-333
    2. G. Hindricks, H. Kottkamp, W. Haverkamp, M. Shenasa, H. Shenasa, M. Borggrefe et al.
      Pages 363-390
  7. Future Perspectives

  8. Back Matter
    Pages 405-410

About this book


Management and prevention of tachyarrhythmias, especially of serious ventricular arrhythmias after myocardial infarction, is still a major problem. Large-scale evidence suggests an increased harm induced by antiarrhythmic drugs in the presence of organic heart disease although they effectively suppress spontaneous arrhythmias. This increased risk has been linked to their proarrhythmic potential and to possible interactions by ischaemia. However, the mechanisms by which antiarrhythmic drugs exert their antiarrhythmic and proarrhythmic actions are still poorly understood. Therefore, it was a time to present an update on the mechanisms of antiarrhythmic and proarrhythmic action of drugs which act on the electrophysiological properties of the heart. World renowned electrophysiologists as well as clinicians have joint to address important topics which range from the effect of antiarrhythmic drugs on single channels and on arrhythmia models to the clinical arena.


Drug action Interactions Ion channel biophysics arrhythmia drug drugs heart kinetics pharmacodynamics pharmacokinetics pharmacology sudden cardiac death

Editors and affiliations

  • Günter Breithardt
    • 1
  • Martin Borggrefe
    • 4
  • A. John Camm
    • 2
  • Mohammad Shenasa
    • 3
  • Wilhelm Haverkamp
    • 1
  • Gerhard Hindricks
    • 1
  1. 1.Medizinische Klinik und Poliklinik, Innere Medizin CWestfälische Wilhelms-Universität MünsterMünsterGermany
  2. 2.Dept. of Cardiological SciencesSt. George’s Hospital Medical School Cranmer TerraceLondonUK
  3. 3.Department of MedicineO’Connor HospitalSan JoseUSA
  4. 4.Department of Cardiology and AngiologyWestfälische Wilhelms-Universität MünsterMünsterGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-85626-6
  • Online ISBN 978-3-642-85624-2
  • Buy this book on publisher's site