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Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones

  • Thomas C. Gasser
Book

Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 27)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Introduction

    1. Thomas C. Gasser
      Pages 1-2
  3. General Considerations

    1. Thomas C. Gasser
      Pages 3-11
  4. In Vitro Studies

    1. Thomas C. Gasser
      Pages 12-12
  5. Animal Studies

    1. Thomas C. Gasser
      Pages 13-17
  6. Human Studies and Review of the Literature

    1. Thomas C. Gasser
      Pages 18-30
  7. Literature

    1. Thomas C. Gasser
      Pages 31-38
  8. Summary

    1. Thomas C. Gasser
      Pages 39-39
  9. Acknowledgments

    1. Thomas C. Gasser
      Pages 40-40
  10. Reprints of papers I – VII

    1. Front Matter
      Pages 41-41
    2. T. C. Gasser, E. H. Larsen, T. Dørflinger, P. O. Madsen
      Pages 43-46
    3. T. C. Gasser, P. H. Graversen, E. H. Larsen, T. Dørflinger
      Pages 47-51
    4. Thomas C. Gasser, Peder H. Graversen, Paul O. Madsen
      Pages 53-56
    5. T. C. Gasser, P. H. Graversen, E. H. Larsen, P. O. Madsen
      Pages 57-62
    6. Thomas C. Gasser, Steven C. Ebert, Peder H. Graversen, Paul O. Madsen
      Pages 63-66
    7. Thomas C. Gasser, Peder H. Graversen, Paul O. Madsen
      Pages 67-68

About this book

Introduction

This monograph gives an excellent review of the issue of antimicrobial prophylaxis in urol­ ogy and the use of the new fluoroquinolones in urology. The development of the fluoro­ quinolones has had a profound effect in urology, specifically because of the unique phar­ macokinetics of the fluoroquinolones with their two or more pK values, making concen­ tration of these compounds possible in the prostate. Their wide spectra against infecting organisms causing infections in the urinary tract have also made them popular and almost ideal in the treatment of urinary tract infections. This thesis summarizes in an concise way and brings up to date practically all our know­ ledge concerning the use of fluoroquinolones in urology. The chapter on antimicrobial prophylaxis covers our present knowledge completely, especially concerning the use of these drugs in antimicrobial prophylaxis in transurethral surgery. September 1992 PaulO. Madsen Madison, Wisconsin, USA v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 1. Author's Publications Referred to in Text . . . . . . . . . . . . . . . . . . . . . . 1 1. 2. Historical Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 3. Problems of Antimicrobial Prophylaxis in Urology . . . . . . . . . . . . . . . . 2 D. General Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 1. Bacteriuria and urinary tract infections . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 2. Bacteremia and septicemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 3. Nosocomial infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. 4. Wound infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 2. Pathophysiology of Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 3. Specifics of Antimicrobial Agents to be Used in Prophylaxis . . . . . . . . . . 6 2. 4. Role of Quinolones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 4. 1. Antimicrobial activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 4. 2. Pharmacokinetic properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Keywords

Transplantation antimicrobial antimicrobial prophylaxis bacteremia bacteria infection infections infectious infectious disease nosocomial infection pathophysiology physiology

Authors and affiliations

  • Thomas C. Gasser
    • 1
  1. 1.Urologic Clinics Department of SurgeryUniversity Hospital (Kantonsspital)BaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-85422-4
  • Copyright Information Steinkopff-Verlag Darmstadt 1992
  • Publisher Name Steinkopff
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7985-0942-9
  • Online ISBN 978-3-642-85422-4
  • Series Print ISSN 0071-7975
  • Buy this book on publisher's site