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Molecular Aspects of Myeloid Stem Cell Development

  • Linda Wolff
  • Archibald S. Perkins

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 211)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Regulation of Myeloid Differentiation, Growth Arrest and Apoptosis

    1. Front Matter
      Pages 1-1
    2. Steven J. Collins, Schickwann Tsai, Irwin Bernstein
      Pages 7-15
    3. B. Hoffman, D. A. Liebermann, M. Selvakumaran, H. Q. Nguyen
      Pages 17-27
  3. Receptors and Signal Transduction

  4. Myb: Proliferation and Maintenance of Stage Specific Genes

    1. Front Matter
      Pages 77-77
    2. H. H. Lin, D. C. Sternfeld, S. G. Shinpock, R. A. Popp, M. L. Mucenski
      Pages 79-87
    3. C. Kanei-Ishii, T. Nomura, K. Ogata, A. Sarai, T. Yasukawa, S. Tashiro et al.
      Pages 89-98
    4. T. J. Gonda, D. Favier, P. Ferrao, E. M. Macmillan, R. Simpson, F. Tavner
      Pages 99-109
  5. Myeloid-Specific Transcription

    1. Front Matter
      Pages 111-111
    2. M. C. Simon, M. Olson, E. Scott, A. Hack, G. Su, H. Singh
      Pages 113-119
    3. F. Barahmand-pour, A. Meinke, Matthias Kieslinger, A. Eilers, T. Decker
      Pages 121-128
    4. G. Twamley-Stein, E. Kowenz-Leutz, S. Ansieau, A. Leutz
      Pages 129-136
    5. D.-E. Zhang, S. Hohaus, M. T. Voso, H.-M. Chen, L. T. Smith, C. J. Hetherington et al.
      Pages 137-147
    6. R. Hromas, B. Davis, F. J. Rauscher III, M. Klemsz, D. Tenen, S. Hoffman et al.
      Pages 159-164
    7. A. Khanna-Gupta, T. Zibello, N. Berliner
      Pages 165-171
  6. Molecular Aspects of Myeloid Leukemia. I. Murine Studies

    1. Front Matter
      Pages 189-189
    2. L. Wolff, R. Koller, J. Bies, V. Nazarov, B. Hoffman, A. Amanullah et al.
      Pages 191-199
    3. E. Rassart, J. Houde, C. Denicourt, M. Ru, C. Barat, E. Edouard et al.
      Pages 201-210
    4. D. A. Largaespada, C. I. Brannan, J. D. Shaughnessy, N. A. Jenkins, N. G. Copeland
      Pages 233-239
  7. Molecular Aspects of Myeloid Leukemia. II. Human Studies

  8. Back Matter
    Pages 299-300

About these proceedings

Introduction

A workshop on "MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT" was held at the Historic Inns in Annapolis, MD during April 30-May 3, with approximately 70 persons attend­ ing. The enormous success of this meeting was attributable to the recent outburst of information generated from two areas of study: transcriptional regulation of developmentally important myeloid genes and molecular dissection of chromosomal abnormalities in human myeloid leukemias. It was reassuring that studies of normal myelopoiesis and abnormal myelopoiesis, as observed in dys­ plasias and neoplasia, are revealing several interrelated mechan­ isms of gene regulation. However, great challenges await us as we try to determine how these and other mechanisms in this intricate system orchestrate the ultimate fate of cells e. g. proliferation, differentiation or apoptosis. This volume of Current Topics in Micro­ biology encapsulates many of the key aspects of the workshop summarizing research over the past few years on the ontogeny and pathology of myeloid cells. Investigations into the complex process of normal myeloid cell . maturation were first made possible through development of in vitro clonigenic assays. These established the relationships of colony stimulating factors, interleukins and their combinations to the specific fates of myeloid progenitors derived from the bone , marrow and spleen. Molecular studies became feasible, however, through the later establishment of several cell culture systems in­ volving immortalized cells which, under the proper induction, could fairly accurately recapitulate the myelopoietic process.

Keywords

Knochenmark apoptosis cell chromosome cytokine growth growth factor hematopoiesis leukemia macrophages protein proteins regulation transcription virus

Editors and affiliations

  • Linda Wolff
    • 1
  • Archibald S. Perkins
    • 2
  1. 1.Laboratory of GeneticsNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Department of PathologyYale University School of MedicineNew HavenUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-85232-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-85234-3
  • Online ISBN 978-3-642-85232-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site