Transgenic Models of Human Viral and Immunological Disease

  • Francis V. Chisari
  • Michael B. A. Oldstone

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 206)

Table of contents

  1. Front Matter
    Pages I-XI
  2. S. D. Khare, H. S. Luthra, C. S. David
    Pages 85-100
  3. H. Arnheiter, M. Frese, R. Kambadur, E. Meier, O. Haller
    Pages 119-147
  4. M. Nerenberg, X. Xu, D. A. Brown
    Pages 175-196
  5. P. E. Klotman, A. L. Notkins
    Pages 197-222
  6. S. M. Toggas, L. Mucke
    Pages 223-241
  7. S. B. Prusiner
    Pages 275-304
  8. V. R. Racaniello, R. Ren
    Pages 305-325
  9. Back Matter
    Pages 341-348

About this book


Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.


Viruses autoimmunity cytokine diseases gene immunity immunodeficiency immunology infection infections pathogenesis tumor tumors virology virus

Editors and affiliations

  • Francis V. Chisari
    • 1
    • 2
  • Michael B. A. Oldstone
    • 3
    • 4
  1. 1.Department of Molecular and Experimental MedicineThe Scripps Research InstituteLa JollaUSA
  2. 2.Division of Experimental PathologyThe Scripps Research InstituteLa JollaUSA
  3. 3.Department of NeuropharmacologyThe Scripps Research InstituteUSA
  4. 4.Division of VirologyThe Scripps Research InstituteUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-85210-7
  • Online ISBN 978-3-642-85208-4
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site