Pathogenicity of Human Herpesviruses due to Specific Pathogenicity Genes

  • Yechiel Becker
  • Gholamreza Darai

Part of the Frontiers of Virology book series (FRVIROLOGY, volume 3)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Herpes Simplex Virus

    1. Front Matter
      Pages 1-1
    2. Genes Involved in Entry

      1. Yechiel Becker, Eynat Tabor, Yael Asher, Mirta Grifman, Yosef Kleinman, Avner Yayon
        Pages 3-20
      2. Anne M. Øyan, Lars Haarr, Joseph C. Glorioso, Karen E. Dolter, Howard S. Marsden, Clyde S. Crumpacker et al.
        Pages 21-32
      3. Yasushi Toh, Yasufumi Hidaka, Yuji Kumano, Hiroko Minagawa, Ryoichi Mori
        Pages 33-42
      4. R. J. Eisenberg, D. Lone, D. L. Sodora, H.-Y. Chiang, W. C. Wilcox, W. R. Abrams et al.
        Pages 43-65
    3. Genes Coding for Enzymes

    4. Genes Related to Intraperitoneal Pathogenicity

      1. Angela Rösen-Wolff, Roland Kehm, Eva Lorentzen, Wolfram Lamade, Gholamreza Darai
        Pages 177-202
    5. Genes and Latency and Intracerebral Pathogenicity

      1. Edward K. Wagner
        Pages 210-221
      2. Myron Levine, David J. Fink, Ramesh Ramakrishnan, Prashant Desai, William F. Goins, Joseph C. Glorioso
        Pages 222-237
    6. Genes and Latency and Intracerebral Pathogenicity

  3. Epstein Barr Virus

    1. Front Matter
      Pages 281-281
    2. Marc Jacquemin, Alison J. Sinclair, Paul J. Farrell
      Pages 283-297
    3. Giuseppe Scala, Ileana Quinto, Maria R. Ruocco, Massimo Mallardo, Concetta Ambrosino, Francesca Baldassarre et al.
      Pages 298-311
  4. Human Cytomegalovirus

    1. Front Matter
      Pages 313-313
    2. Jessica M. Boname, Laurel A. Lagenaur, Edward S. Mocarski
      Pages 315-328
  5. Human Herpesvirus-6

    1. Front Matter
      Pages 329-329
    2. Abdur Razzaque, Koichi Yamanishi, Donald R. Carrigan
      Pages 331-343
  6. Trends

  7. Back Matter
    Pages 381-387

About this book


Six members of the Herpesviridae family are human pathogens, including herpes and 2 (HSV-I and 2), Epstein-Barr virus (EBV), varicella zoster simplex virus I virus (VZV), human cytomegalovirus (HCMV), and human herpesvirus 6 (HHV 6). Each of these viruses is capable of causing distinct diseases of varying severity in children, young adults, and the aged. The diseases range from infection of epithelial tissue to the infection of internal organs and white blood cells. A common feature of the six pathogenic human herpesviruses is their ability to latently infect different cell types in which the viral DNA is not integrated and is unable to express its pathogenicity. Reactivation of the herpesviruses is a result of cellular processes which reactivate viral genes, leading to virus progeny and to signs of infection. Due to their ability to become latent after initial infection, once the pathogenic herpesviruses infect children they are maintained throughout life, having the potential of cause various diseases upon reactivation.


Cytomegalovirus Epstein Barr Virus Herpes Simplex Virus Herpesvirus Human Herpesvirus-6 Varicella Zoster Virus Viruses biology gene infection molecular biology tissue vaccine virus

Editors and affiliations

  • Yechiel Becker
    • 1
  • Gholamreza Darai
    • 2
  1. 1.Department of Molecular Virology, Institute of Microbiology, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Institut für Medizinische VirologieUniversität HeidelbergHeidelbergGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1994
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-85006-6
  • Online ISBN 978-3-642-85004-2
  • Series Print ISSN 1431-357X
  • Buy this book on publisher's site