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Infectious Complications in Bone Marrow Transplantation

  • Stephen C. Schimpff
  • Jean Klastersky

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 132)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Introduction

  3. Case Presentation

    1. S. C. Schimpff
      Pages 35-44
  4. Infection and Granulocytopenia

  5. Infections and Cellular Immune Dysfunction

  6. Infections Related to Humoral Immune Deficiency Vascular Access/Transfusions

  7. New Pathogens/Resistance/Drug Delivery

    1. S. H. Zinner
      Pages 231-240
    2. G. A. Jacoby
      Pages 241-247
  8. Clinical Trials: Perspectives

  9. Back Matter
    Pages 279-284

About these proceedings

Introduction

As the demographics of the population shift toward an increasingly aged society, the number of individuals with cancer increases and with it the need to give the most comprehensive possible health care delivery. Although much has been written about the specific therapy best suited for the various types of cancer and about the basic and clinical research which has dramatically improved treat­ ment, overall patient care requires attention to supportive care, which includes such items as pain management, the use of blood products, nutrition, and psychosocial needs. Yet infection remains the leading cause of death in cancer patients and is a major cause of morbidity and hospitaliza­ tion, making it a major aspect of the supportive care of cancer patients. It therefore deserves a full exposition. Bone marrow transplantation is increasingly being utilized as part of a therapeutic modality in the treatment of cancer patients. Transplantation patients are at such a particularly high risk of developing a wide variety of different types of infection, that they inevitably can serve as an excellent framework for discussion of all the types of infections that occur during the treatment of cancer. The patient undergoing allogeneic bone marrow transplantation is at particularly high risk of infection due to the major perturbations of host defenses, which include granulo­ cytopenia, cellular immune dysfunction, humoral immune dysfunction, blood product transfusions, and vascular access devices. Each of these perturbations results in a different set of infectious disease problems.

Keywords

Bone marrow transplantation bone marrow cancer chemotherapy clinical trial infection oncology prevention transplantation

Editors and affiliations

  • Stephen C. Schimpff
    • 1
  • Jean Klastersky
    • 2
  1. 1.University of Maryland Medical SystemBaltimoreUSA
  2. 2.Institut Jules BordetCentre des Tumeurs de l’Université Libre de BruxellesBrusselsBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-84899-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84901-5
  • Online ISBN 978-3-642-84899-5
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site