Recent Advances in Cell Biology of Acute Leukemia

Impact on Clinical Diagnosis and Therapy

  • Wolf-Dieter Ludwig
  • Eckhard Thiel

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 131)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Hematopoietic Differentiation

  3. Phenotypic Heterogeneity in Acute Leukemias: Immunological Characterization and Clinical Relevance

    1. E. Matutes, V. Buccheri, R. Morilla, V. Shetty, M. Dyer, D. Catovsky
      Pages 41-52
    2. F. M. Fink, U. Köller, H. Mayer, O. A. Haas, E. R. Grümayer, C. Urban et al.
      Pages 67-75
    3. E. R. van Wering, P. Brederoo, G. J. van Staalduinen, J. van der Meulen, B. E. M. van der Linden-Schrever, J. J. M. van Dongen
      Pages 77-87
  4. Biological and Clinical Significance of Cytogenetic Abnormalities in Acute Leukemias

    1. O. A. Haas, M. Kronberger, L. Mayerhofer
      Pages 103-112
    2. W. Hiddemann, J. Harbott, W.-D. Ludwig, J. Ritter, A. Nehmer, A. Reiter et al.
      Pages 113-121
    3. J. Harbott, J. Ritterbach, W.-D. Ludwig, C. R. Bartram, A. Reiter, F. Lampert
      Pages 123-132
    4. H. Rieder, W.-D. Ludwig, W. Gassmann, E. Thiel, H. Löffler, D. Hoelzer et al.
      Pages 133-148
  5. Minimal Residual Disease in Acute Leukemias: Detection and Immunotherapeutic Strategies

  6. Immunophenotypic and Molecular Genetic Characterization of Acute Lymphoblastic Leukemia: Biological and Clinical Implications

    1. H. Tesch, M. Jücker, H. Abts, R. Laumann, W.-D. Ludwig, I. Pahl
      Pages 239-247
    2. R. Pieters, G. J. L. Kaspers, E. R. van Wering, D. R. Huismans, A. H. Loonen, K. Hählen et al.
      Pages 249-256
    3. M. J. Borowitz, A. J. Carroll, J. J. Shuster, A. T. Look, F. G. Behm, D. J. Pullen et al.
      Pages 257-267
    4. W.-D. Ludwig, J. Harbott, C. R. Bartram, B. Komischke, C. Sperling, J. V. Teichmann et al.
      Pages 269-282
    5. G. Basso, R. Rondelli, M. C. Putti, A. Cantù Rajnoldi, D. Granchi, M. G. Cocito et al.
      Pages 297-307
  7. Leukemic Cell Characterization in Acute Myeloid Leukemia: Biological and Clinical Implications

    1. M. Lübbert, W. Oster, F. McCormick, R. Mertelsmann, F. Herrmann
      Pages 315-327
    2. T. Pietsch, U. Kyas, H. G. Drexler, K. Welte
      Pages 329-338
    3. A. Biondi, A. Rambaldi, P. P. Pandolfi, M. Alcalay, L. Longo, V. Rossi et al.
      Pages 345-359
    4. O. A. Haas, U. Köller, N. Grois, H. Nowotny
      Pages 361-368
    5. A. Orfao, B. Vidriales, M. Gonzalez, M. C. Lopez-Berges, M. C. del Cañizo, J. F. San Miguel
      Pages 369-379
    6. C. Sperling, H. Seibt-Jung, W. Gassmann, B. Komischke, C. Sauerland, W. Hiddemann et al.
      Pages 381-392
    7. J. F. San Miguel, J. M. Hernandez, R. Gonzalez, M. Gonzalez, I. Sanchez, A. Orfao et al.
      Pages 393-400
  8. Back Matter
    Pages 401-407

About these proceedings


The development of new techniques such as immuno­ phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono­ clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho­ genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo­ somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop­ ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell­ biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con­ tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.


Acute Leukemia Akute Leukämien Antigen Cytogenetics Immunophenotype Immunphänotype Molecular-cell biology Molekularbiologie Zytogenetik classification minimal residual disease

Editors and affiliations

  • Wolf-Dieter Ludwig
    • 1
  • Eckhard Thiel
    • 1
  1. 1.Abt. Hämatologie/OnkologieUniversitätsklinikum SteglitzBerlin 45Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84897-1
  • Online ISBN 978-3-642-84895-7
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site