Cancer Therapy

Differentiation, Immunomodulation and Angiogenesis

  • Natale D’Alessandro
  • Enrico Mihich
  • Luciano Rausa
  • Haim Tapiero
  • Thomas R. Tritton
Conference proceedings

Part of the NATO ASI Series book series (volume 75)

Table of contents

  1. Front Matter
    Pages I-XI
  2. A. Zweibaum, T. Lesuffleur, A. Barbat, E. Dussaulx, I. Chantret, L. Mahraoui et al.
    Pages 1-15
  3. E. Huberman, D. A. Tonetti, M. Horio, S. Murao, F. R. Collart
    Pages 17-32
  4. G. B. Rossi, G. Romeo, A. Battistini, E. Affabris, E. M. Coccia, G. Fiorucci
    Pages 71-89
  5. Asterios S. Tsiftsoglou, Athina I. Tsamadou, Stephen H. Robinson, Willie Wong
    Pages 109-120
  6. Enrico Mihich, M. Jane Ehrke
    Pages 121-133
  7. P. Puccetti, U. Grohmann, R. Bianchi, L. Binaglia, M. L. Belladonna, M. Allegrucci et al.
    Pages 147-161
  8. Carlo Gambacorti-Passerini, Giorgio Parmiani, Pier Adelchi Ruffini
    Pages 179-187
  9. M. Crescimanno, N. Borsellino, V. Leonardi, L. Rausa, N. D’Alessandro
    Pages 201-208
  10. M. R. Soma, R. Baetta, C. Ferrari, M. R. de Renzis, R. Paoletti, R. Fumagalli
    Pages 217-223
  11. F. Squadrito, A. P. Caputi
    Pages 225-230
  12. Alberto Mantovani, Barbara Bottazzi, Silvano Sozzani, Giuseppe Peri, Paola Allavena, Cecilia Garlanda et al.
    Pages 249-258
  13. R. Danesi, M. Costa, C. Agen, U. Benelli, M. Del Tacca
    Pages 269-273
  14. M. Ziche, L. Morbidelli, A. Parenti, G. Alessandri, F. Ledda, P. M. Gullino
    Pages 275-279
  15. Back Matter
    Pages 281-292

About these proceedings


Provided here is a comprehensive examination of the basic and clinical condition of three innovative and promising approaches to cancer therapy, which may support or even substitute chemotherapy: differentiation, immunomodulation, and inhibition of angiogenesis. Differentiation shouldnormalize neoplastic cells and make them compatible with the host. Its feasibility with retinoids, interferons, chemotherapeutic and other agents is discussed. Modulation by biological agents, cytotoxic effector cells and drugs is considered in attempts to boost endogenous antitumour defenses and/or to render neoplastic cells more susceptible to the immune attack of the host. Finally, the important aspect of interfering with tumour blood vessel development and function is taken into account. Consideringthe importance that chemotherapy has in cancer treatment and in view of a more and more integrated strategy, the relationship between the aforementioned approaches and chemotherapeutic agents and chemoresistance is treated in detail.


Angiogenese Immunodulation Krebs Onkologie angiogenesis cancer chemoresistance cheotherapy immunomodulation interferon oncology tumour

Editors and affiliations

  • Natale D’Alessandro
    • 1
  • Enrico Mihich
    • 2
  • Luciano Rausa
    • 3
  • Haim Tapiero
    • 4
  • Thomas R. Tritton
    • 5
  1. 1.Institute of PharmacologyMessinaItaly
  2. 2.Grace Cancer Drug Center, Department of Experimental TherapeuticsRoswell Park Center InstituteBuffaloUSA
  3. 3.Policlinic of the University “P. Giaccone”PalermoItaly
  4. 4.Laboratoire de Pharmacologie Cellulaire & Moleculaire, ICIGHopital Paul-BrousseVillejuifFrance
  5. 5.School of MedicineUniversity of VermontBurlingtonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84615-1
  • Online ISBN 978-3-642-84613-7
  • Buy this book on publisher's site