Concomitant Continuous Infusion Chemotherapy and Radiation

  • Marvin Rotman
  • C. Julian Rosenthal

Part of the Medical Radiology book series (MEDRAD)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. The Development of Chemotherapy Drugs as Radiosensitizers: an Overview

    1. C. Julian Rosenthal, Marvin Rotman
      Pages 1-9
  3. Principles of Infusion Chemotherapy

    1. Front Matter
      Pages 11-11
    2. R. Brian Mitchell, Mark J. Ratain, Nicolas J. Vogelzang
      Pages 13-27
    3. Leonard Saltz, Morton Coleman, Peter Yi
      Pages 29-34
    4. Reinhard von Roemeling, Rosellen Lanning, Henry Wagner Jr., Ronald DeConti, Lawrence E. Scheving, William Hrushesky
      Pages 57-65
  4. Radiosensitization and Radioprotection

    1. Front Matter
      Pages 75-75
    2. C. Norman Coleman
      Pages 77-84
    3. Dwight Kaufman, James B. Mitchell, Angelo Russo
      Pages 85-89
    4. Richard G. Evans, Bruce F. Kimler, Robert A. Morantz, Tribhawan S. Vats, Vici Liston, Norma L. Lowe
      Pages 97-100
    5. Gary B. Thurman, Robert K. Oldham
      Pages 105-111
  5. 5-Fluorouracil Radiopotentiation and Its Modulation by Other Agents

    1. Front Matter
      Pages 113-113
    2. Marvin Rotman, Hassan Aziz, Seth Reiner, C. Julian Rosenthal, Jean-Philippe Austin, Richard S. Stark
      Pages 137-142
    3. Lawrence R. Coia, Patrick Stafford, Paul F. Engstrom, Anthony R. Paul, Gerald E. Hanks
      Pages 143-148
    4. Bernard J. Cummings, Thomas J. Keane, A. Michael Rauth
      Pages 149-159
    5. Marvin Rotman, Hassan Aziz, Louis Potters, Kwang Choi
      Pages 167-173
    6. Kenneth J. Russell, Celestia S. Higano, Michel A. Boileau, Anthony H. Russell, Caroline Collins, Wui-Jin Koh et al.
      Pages 175-180
  6. Radiopotentiation by Cisplatin in Continuous Infusion

    1. Front Matter
      Pages 189-189
    2. Evan B. Douple, Marcia L. Wills, Ellen L. Jones
      Pages 191-196
    3. Kwang Choi, Marvin Rotman, Hassan Aziz, C. Julian Rosenthal, Richard S. Stark, Jose R. Marti
      Pages 197-203
    4. Rolf Sauer, Jürgen Dunst
      Pages 205-216
    5. Andrew T. Turrisi III
      Pages 217-221
    6. Hassan Aziz, C. Julian Rosenthal, Louis Potters, Mohan Nuthakki, Marvin Rotman
      Pages 223-228
  7. Radiopotentiation by Combined Cisplatin and Continuous Infusion 5-Fluorouracil

    1. Front Matter
      Pages 229-229
    2. Samuel G. Taylor IV, Katherine Griem
      Pages 231-237
    3. Alfred DiStefano, Samuel L. Jampolis, George R. Blumenschein, Barry A. Firstenberg, John P. Kelly, Jose E. Gomez-Yeyille
      Pages 243-245
    4. Madhu J. John
      Pages 247-253
    5. Gary V. Burton, Walter G. Wolfe, Ian Crocker, Hilliard F. Seigler, Leonard R. Prosnitz, Jeffrey Crawford
      Pages 255-257
  8. Efficacy of Continuous Infusion Adriamycin as a Radiation Potentiator

    1. Front Matter
      Pages 269-269
    2. Richard S. Stark, C. Julian Rosenthal, Marvin Rotman
      Pages 281-284
  9. Back Matter
    Pages 285-306

About this book


The administration of chemotherapeutic agents by continuous infusion with concomitant radiation therapy heralds a new approach in the treatment of cancer. This comprehensive book on the subject includes, besides a discussion of its scientific basis, the most promising clinical data on the use of continuous infusion chemotherapy and radiation. Thus, it is an important update for clinical investigators involved in frontline research as well as for practicing physicians participating in the direct care of cancer patients. The contributions include the latest results of this new approach in a number of tumor sites. There is a detailed description of the principles of radiosensitization for malignant tumors and radioprotection for normal tissues; these are the principles which have led to concrete clinical applications. There is also a presentation of the most recent data on the beneficial effects resulting from the administration of commonly used drugs, such as 5-fluorouracil, cisplatinum and adriamycin, with concomitant radiation therapy. Much of the data has never before been published. The wealth of information in this volume makes it a valuable reference; at the same time it gives practicing physicians a detailed presentation of various therapeutic regimens which they could administer in their daily clinical practice. In the future, this innovative cancer treatment may lead to the decreased need for radical surgery and the increased ability to preserve organ function.


Tumor brain brain tumors cancer cancer treatment carcinoma cell chemotherapy clinical trial metastasis radiation radiation therapy radiology radiotherapy surgery

Editors and affiliations

  • Marvin Rotman
    • 1
  • C. Julian Rosenthal
    • 1
  1. 1.SUNY Health Science Center at BrooklynState University of New YorkBrooklynUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84188-0
  • Online ISBN 978-3-642-84186-6
  • Series Print ISSN 0942-5373
  • Buy this book on publisher's site