Tissue Oxygen Utilization

  • Guillermo Gutierrez
  • Jean Louis Vincent

Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 12)

Table of contents

  1. Front Matter
    Pages i-ix
  2. D. P. Jones, T. Y. Aw, D. P. Kowalski
    Pages 1-15
  3. A.-M. Seymour
    Pages 16-32
  4. C. A. Piantadosi, W. J. Parsons, J. A. Griebel
    Pages 41-55
  5. J. Almirall, G. Hedenstierna
    Pages 87-102
  6. P. T. Schumacker, R. W. Samsel
    Pages 132-142
  7. R. Schlichtig, J. V. Snyder, M. R. Pinsky
    Pages 143-159
  8. S. Zakynthinos, C. Roussos
    Pages 171-184
  9. L. G. Thijs, A. B. J. Groeneveld
    Pages 200-216
  10. J.-F. Dhainaut, G. Annat, A. Armaganidis
    Pages 217-226
  11. G. Gutierrez, A. Dubin
    Pages 227-241

About this book

Introduction

Disturbances in peripheral O extraction can be produced in dogs treated with 2 endotoxin and thereby provide an opportunity to test theories for the origin of pathological O supply dependency or to try different treatment modalities. The 2 most serious deficiency in the current animal models is the inability to mimic the increased O demand that is observed in patients at 02 delivery rates in excess of 2 normal. A particular feature of this increased O demand is that it apparently does 2 not stimulate increased 02 extraction, although the limitation in O extraction has 2 not been explored in patients by lowering 02 supply, for obvious reasons. At least two possibilities to account for increased 02 demand could be investigated in animal models, however. The amount of 02 that is utilized in extramitochondrial pathways, which is normally on the order of 10%, may be greatly increased in ARDS and sepsis by O radical formation. There is presently no information 2 concerning how much 02 might be used in this way. Another strong possibility is that mitochondrial injury, perhaps as a result of 02 radical formation, uncouples oxidative phosphorylation. Some evidence presently in the literature supports this idea [19]. Indeed, the association of increased blood lactate levels with higher than expected 02 demands makes uncoupling a very attractive hypothesis that warrants further investigation in animal models using such agents as 2,4-dinitrophenol. References 1.

Keywords

Hypoxie Intensivmedizin Sauerstoffzufuhr und -verbrauch Sepsis Surgery anesthesia care hypoxia intensive care intensive care medicine multiple organ failure oxygen delivery and consumption shock tissue zellulärer Stoffwechsel

Editors and affiliations

  • Guillermo Gutierrez
    • 1
  • Jean Louis Vincent
    • 2
  1. 1.Pulmonary MedicineHealth Science CenterHoustonUSA
  2. 2.Department of Intensive Care, Erasme University HospitalFree University of BrusselsBrusselsBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-84169-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-52472-4
  • Online ISBN 978-3-642-84169-9
  • Series Print ISSN 0933-6788
  • About this book