Activation and Desensitization of Transducing Pathways

  • T. M. Konijn
  • M. D. Houslay
  • P. J. M. Van Haastert
Conference proceedings

Part of the NATO ASI Series book series (volume 44)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Chemotaxis and chemosensing

    1. Front Matter
      Pages 1-1
    2. Roxanne Vaughan, Ronald Johnson, Michael Caterina, Peter Devreotes
      Pages 23-40
    3. Peter J. M. Van Haastert, Anthony A. Bominaar, Jeroen Van der Kaay, Richard Draijer, Louis C. Penning, Edwin Roovers et al.
      Pages 41-59
  3. Cyclic nucleotide-coupled systems

  4. Inositol phospholipid-cupled systems

    1. Front Matter
      Pages 151-151
    2. Isabel Varela, Jose F. Alvarez, Jose Puerta, Rosa Clemente, Ana Guadaño, Matias Avila et al.
      Pages 167-179
    3. J. L. Boyer, M. W. Martin, C. L. Cooper, G. L. Waldo, A. J. Morris, H. A. Brown et al.
      Pages 181-195
  5. G-protein activation

    1. Front Matter
      Pages 197-197
    2. K. H. Jakobs, T. Wieland, P. Gierschik
      Pages 199-212
  6. Visual transduction

    1. Front Matter
      Pages 213-213
  7. Āuxin-coupled systems

    1. Front Matter
      Pages 229-229
    2. H. Barbier-Brygoo, G. Ephritikhine, W. H. Shen, A. Delbarre, D. Klämbt, J. Guern
      Pages 231-244
    3. Gero Viola, Ulrich Tillmann, Thomas Hesse, Beate Knauth, Klaus Palme, Marian Löbler et al.
      Pages 245-253
    4. B. Zbell, H. Hohenadel, I. Schwendemann, C. Walter-Back
      Pages 255-266
  8. Ion conductance

    1. Front Matter
      Pages 267-267
    2. C. Mulle, P. Benoit, F. Revah, J. P. Changeux
      Pages 269-281
  9. Cellular systems

    1. Front Matter
      Pages 283-283
    2. S. Reuse, C. Maenhaut, A. Lefort, F. Libert, M. Parmentier, E. Raspé et al.
      Pages 285-306
    3. E. Sher, S. Denis-Donini, A. Zanini, C. Bisiani, E. Biancardi, F. Clementi
      Pages 307-320
  10. Back Matter
    Pages 321-323

About these proceedings


Activation by and desensitization to signals originating from the environment is common in all organisms, ranging from prokaryotes to higher eukaryotes. Recently, a number of novel mechanisms involved in activation and desensitization have been elucidated. The similarities of the molecular mechanisms of activation and desensitization in the various systems are striking. In the first book (1987) on this topic, the functional and structural similarities of the various mechanisms to attenuate the effect of an outward signal were emphasized. Justification to have a second book three years later is the explosive growth of information in the field. More components involved in signal transfer have been discovered and also that several more G-proteins appear to play a role during this process. The interest in signal attenuation concurs with these developments. The emphasis in this book is on the common signal transfer elements responsible for activation and desensitization in animals, plants and microorganisms.


Activation Aktivierung, molekulare Desensibilisierung G-Proteine Pharmakologie Signalweiterleitung molecular mechanisms proteins

Editors and affiliations

  • T. M. Konijn
    • 1
  • M. D. Houslay
    • 2
  • P. J. M. Van Haastert
    • 3
  1. 1.Zoölogisch LaboratoriumLeidenThe Netherlands
  2. 2.Institute of BiochemistryThe University of GlasgowGlasgowScotland
  3. 3.Biochemisch LaboratoriumGroningenThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-83620-6
  • Online ISBN 978-3-642-83618-3
  • Buy this book on publisher's site