Perioperative Chemotherapy

Rationale, Risk and Results

  • Urs Metzger
  • Felix Largiadèr
  • Hans-Jörg Senn

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 98)

Table of contents

  1. Front Matter
    Pages I-XII
  2. General Aspects

  3. Breast Cancer

    1. R. Nissen-Meyer, H. Host, K. Kjellgren, B. Mansson, T. Norin
      Pages 91-98
    2. J. Ragaz, R. Baird, R. Rebbeck, A. Goldie, A. Coldman, J. Spinelli
      Pages 99-105
    3. Urs Metzger, Felix Largiadèr, Hans-Jörg Senn
      Pages 114-115
  4. Various Tumors

  5. Summary

    1. U. Metzger, F. Largiadér, H.-J. Senn
      Pages 153-155
  6. Back Matter
    Pages 156-160

About this book


One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas­ tases from it might be enhanced by suppression of immune and reticu­ loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro­ cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.


Krebs cancer metastasis morbidity operative Therapie postoperative Therapie surgery tumor tumor growth

Editors and affiliations

  • Urs Metzger
    • 1
  • Felix Largiadèr
    • 2
  • Hans-Jörg Senn
    • 3
  1. 1.Chirurgische Onkologie Departement ChirurgieUniversitätsklinikZürichSwitzerland
  2. 2.Departement ChirurgieUniversitätsklinikZürichSwitzerland
  3. 3.Medizinische Klinik CKantonsspital St. GallenSt. GallenSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-82434-0
  • Online ISBN 978-3-642-82432-6
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site