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Predictive Drug Testing on Human Tumor Cells

  • Victor Hofmann
  • Michael E. Berens
  • Georg Martz

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 94)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Clonogenic Assays for Solid Tumors

  3. Predictive Tests for Hematological Malignancies

  4. Non-Clonogenic Assays for Drug Testing

    1. O. Sanfilippo, M. G. Daidone, N. Zaffaroni, R. Silvestrini
      Pages 127-139
    2. R. Silvestrini, O. Sanfilippo, M. G. Daidone, N. Zaffaroni
      Pages 140-150
    3. L. M. Weisenthal, R. H. Shoemaker, J. A. Marsden, P. L. Dill, J. A. Baker, E. M. Moran
      Pages 161-173
  5. Evaluation of In Vitro Results

    1. M. Rozencweig, M. Staquet
      Pages 174-183
    2. D. S. Alberts, J. Einspahr, R. Ludwig, S.E. Salmon
      Pages 184-190
  6. Pharmacology Phase II Studies and New Drug Development

    1. C. U. Ludwig, B. G. M. Durie, S. E. Salmon, T. E. Moon
      Pages 220-223
    2. C. Sauter, M. Cogoli, S. Arrenbrecht, C. Marti
      Pages 232-236
    3. B. F. Issell, J. J. Catino, E. C. Bradley
      Pages 237-244
    4. U. Eppenberger, W. Küng, R. Löser, W. Roos
      Pages 245-252
  7. Modulation of Tumor Growth by Non-Chemotherapeutic Intervention

    1. G. Spitzer, F. Baker, G. Umbach, V. Hug, B. Tomasovic, J. Ajani et al.
      Pages 253-266
    2. J. F. Eliason, A. Fekete, N. Odartchenko
      Pages 267-275
  8. Back Matter
    Pages 283-288

About this book

Introduction

Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity. The advantages of an effective test would lie in obviating the need for testing antineoplastic agents on large cohorts of patients for assessment of drug activity (phase II studies) and in allowing determination of optimal use of anticancer agents (phase III trials). Such an in vitro test could help to better define dose and schedule of drugs preclinically. The additive value of individual drugs could be determined on tumor cells in vitro in order to define the best combination chemotherapy in vivo. Test-directed therapy would avoid unnecessary drug-related morbidity in patients with refractory tumors. Chemotherapy treatment would be more than justified even with side effects if palliation or even prolonged survival could be anticipated as a result. The benefits of predictive drug testing on human tumor cells would extend beyond improvement of individual patient treatment if the testing helped to identify new active agents. This spectrum of benefits to the entire field of oncology pro­ vides tremendous motivation for the development of such testing. Although a number of chemosensitivity tests have been proposed since the advent of modern anticancer chemotherapy, interest has been renewed by the possibility of cloning human tumor cells on agar plates, with a view to testing drug activity on cells with high pro­ liferation capacity.

Keywords

Cells cancer chemotherapy drug morbidity tumor tumors

Editors and affiliations

  • Victor Hofmann
    • 1
  • Michael E. Berens
    • 2
  • Georg Martz
    • 1
  1. 1.Department für Innere Medizin, Abteilung für OnkologieUniversitätsspital ZürichZürichSwitzerland
  2. 2.Department of Obstetrics GynecologyBowman Gray, School of MedicineWinston SalemUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-82295-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1984
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-82297-1
  • Online ISBN 978-3-642-82295-7
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site