Selective Heat Sensitivity of Cancer Cells

  • Alessandro Rossi-Fanelli
  • Renato Cavaliere
  • Bruno Mondovì
  • Guido Moricca

Table of contents

  1. Front Matter
    Pages I-XII
  2. B. C. Giovanella, B. Mondovi
    Pages 1-6
  3. R. Strom, C. Crifo, A. Rossi-Fanelli, B. Mondovi
    Pages 7-35
  4. Alessandro Rossi-Fanelli, Renato Cavaliere, Bruno Mondovì, Guido Moricca
    Pages 111-111
  5. G. Moricca, R. Cavaliere, A. Caputo, A. Bigotti, F. Colistro
    Pages 112-152
  6. R. T. Pettigrew, C. M. Lugate
    Pages 153-170
  7. J. S. Stehlin Jr., B. C. Giovanella, P. D. de Ipolyi, L. R. Muenz, R. F. Anderson, A. A. Gutierrez
    Pages 171-185
  8. Back Matter
    Pages 187-192

About this book


Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio­ chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.


Heat Sensitivity cancer cell tumors

Editors and affiliations

  • Alessandro Rossi-Fanelli
    • 1
    • 2
  • Renato Cavaliere
    • 3
  • Bruno Mondovì
    • 4
  • Guido Moricca
    • 3
  1. 1.Institute of Biological ChemistryUniversity of RomeRomeItaly
  2. 2.Center of Molecular BiologyC.N.R.RomeItaly
  3. 3.Regina Elena Institute for Cancer ResearchRomeItaly
  4. 4.Institute of Applied BiochemistryUniversity of RomeRomeItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1977
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81082-4
  • Online ISBN 978-3-642-81080-0
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site