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Metabolic Interconversion of Enzymes 1973

Third International Symposium held in Seattle, June 5–8, 1973

  • E. H. Fischer
  • E. G. Krebs
  • H. Neurath
  • E. R. Stadtman
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Introductory Remarks

    1. Carl F. Cori
      Pages 1-5
  3. Phosphorylation-Dephosphorylation

    1. Glycogen Phosphorylase

      1. David J. Brooks, Stephen J. W. Busby, Raymond A. Dwek, John R. Griffiths, George K. Radda
        Pages 7-19
      2. H. Buc, M. H. Buc, F. Garcia Blanco, M. Morange, H. Winkler
        Pages 21-31
      3. Philip Cohen, John F. Antoniw, Michael Davison, Carol Taylor
        Pages 33-42
      4. D. Gratecos, T. Detwiler, E. H. Fischer
        Pages 43-52
      5. Donald J. Graves, Todd M. Martensen, Jan-I Tu, George M. Tessmer
        Pages 53-61
    2. Glycogen Synthetase

      1. J. Larner, C. H. Smith, A. M. Rosenkrans, T. B. Miller Jr., L. C. Huang, C. Villar-Palasi et al.
        Pages 63-73
      2. Harold L. Segal, David C. Lin
        Pages 75-87
      3. H. G. Hers, W. Stalmans, H. De Wulf, M. Laloux, L. Hue
        Pages 89-98
    3. Pyruvate Dehydrogenase Complex

      1. Lester J. Reed, Flora H. Pettit, Thomas E. Roche, Peter J. Butterworth, Cecilio R. Barrera, C. Stanley Tsai
        Pages 99-106
      2. Ronald H. Cooper, Richard M. Denton, Helen T. Pask, Philip J. Randle, David L. Severson, Sue Whitehouse
        Pages 107-116
      3. Otto H. Wieland, Ludwig Weiss, Georg Löffler, Ingrid Brunner, Sabine Bard
        Pages 117-129
    4. Cyclic AMP Dependent and Independent Protein Kinases

      1. Donald M. Powers, Ann Ginsburg
        Pages 131-142
    5. Phosphorylation of Non-Enzymatic Proteins

      1. Alphonse Krystosek, Lawrence F. Bitte, David Kabat
        Pages 165-173
      2. P. J. England, J. T. Stull, T. S. Huang, E. G. Krebs
        Pages 175-184
      3. H. E. Blum, S. Pocinwong, E. H. Fischer
        Pages 197-208
  4. Adenylylation, Uridylylation and ADP-Ribosylation

    1. Glutamine Synthetase

    2. Escherichia coli RNA Polymerase

    3. Diphtheria Toxin

      1. R. John Collier, Rae Drazin, Judith Kandel, Robert J. DeLange, Dominic W. Chung
        Pages 245-256
  5. Other Types of Covalent Modifications

    1. SH-SS Interchange

      1. B. L. Horecker, S. Pontremoli, S. Traniello, K. Nakashima, J. Rosenberg
        Pages 271-284
    2. Limited Proteolysis

  6. Protein-Protein Interactions

    1. C. Patrick Dunne, Robert C. Menson, John A. Gerlt, Willis A. Wood
      Pages 349-360
    2. Leonard A. Fahien, Susannah E. Smith
      Pages 369-378
    3. Alberto Sols, Richard E. Reeves, Carlos Gancedo
      Pages 393-399
  7. Back Matter
    Pages 400-402

About these proceedings

Introduction

The First International Symposium on the Metabolic Interconversion of Enzymes was held in Santa Margherita Ligure, Italy, in May, 1970, under the direction of Professor G. Bonsignore. Because of rapid developments in this field, a second Symposium was organized a year and a half later in Rottach-Egern, Germany (October, 1971) by Professors E. He1mreich, H. Holzer and O. Wieland. At that time, so much new information had accumulated that it was decided to repeat such conferences approx­ imately every other year; the United States was chosen as the next site. This publi­ cation reports the Proceedings of the Third International Symposium on the Metabolic Interconversion of Enzymes held at the Battelle Seattle Research Center, Seattle, Washington, June 5 - 8, 1973. The conferences were originally designed to examine the control of metabolic reactions by covalent modification of certain key enzymes. Covalent, as opposed to allosteric or metabolic, regulation had first been recognized some fifteen years be­ fore. Initially thought to represent an added sophistication in regulatory processes possibly reserved to higher organisms, covalent regulation has now been found in both prokaryotes and eukaryotes. Those early studies in covalent modification revealed for the first time the existence of special "converter" enzymes whose purpose in life is to switch other molecules from one state of activity to another.

Keywords

Enzymes Fischer Krebs cancer eukaryotes

Authors and affiliations

  • E. H. Fischer
    • 1
  • E. G. Krebs
    • 2
  • H. Neurath
    • 1
  • E. R. Stadtman
    • 3
  1. 1.Department of BiochemistryUniversity of WashingtonSeattleUSA
  2. 2.Department of Biological ChemistryUniversity of California, School of MedicineDavisUSA
  3. 3.National Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-80817-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1974
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80819-7
  • Online ISBN 978-3-642-80817-3
  • Buy this book on publisher's site