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DNA Vaccination/Genetic Vaccination

  • Hilary Koprowski
  • David B. Weiner

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 226)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. P. A. Benton, R. C. Kennedy
    Pages 1-20
  3. B. Wang, A. P. Godillot, M. P. Madaio, D. B. Weiner, W. V. Williams
    Pages 21-35
  4. D. L. Doolan, R. C. Hedstrom, M. J. Gardner, M. Sedegah, H. Wang, R. A. Gramzinski et al.
    Pages 37-56
  5. B. T. Rouse, S. Nair, R. J. D. Rouse, Z. Yu, N. Kuklin, K. Karem et al.
    Pages 69-78
  6. L. A. Babiuk, P. J. Lewis, S. Drunen Little-Van van den Hurk, S. Tikoo, X. Liang
    Pages 90-106
  7. M. L. Bagarazzi, J. D. Boyer, V. Ayyavoo, D. B. Weiner
    Pages 107-143
  8. J. F. Warner, D. J. Jolly, J. Merritt
    Pages 145-160
  9. M. G. Agadjanyan, B. Wang, S. B. Nyland, D. B. Weiner, K. E. Ugen
    Pages 175-192
  10. Back Matter
    Pages 193-201

About this book

Introduction

Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec­ tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene­ delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop­ ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro­ duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.

Keywords

AIDS DNA autoimmune disease cancer gene therapy hepatitis hepatitis B immunodeficiency immunotherapy infection malaria protein vaccination vaccine virus

Editors and affiliations

  • Hilary Koprowski
    • 1
  • David B. Weiner
    • 2
  1. 1.Department of Microbiology and Immunology Center for NeurobiologyThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of Medicine Hospital of the University of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-80475-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80477-9
  • Online ISBN 978-3-642-80475-5
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site